Results 71 to 80 of about 1,748 (246)

Silver nanoparticles-based green fluorescent probe for determination of Bosentan in pharmaceutical formulation and spiked plasma samples

BMC Chemistry
In this work, a new, sensitive, precise, accurate, and eco-friendly spectrofluorometric method for the detection of Bosentan in human plasma and pharmaceutical dosage form was developed, using silver nanoparticles (AgNPs) as an efficient fluorescence ...
Yossra A. Trabik, Rehem A. Ismail, Miriam F. Ayad, Lobna A. Hussein   +3 more
doaj   +1 more source

Green metrics and green analytical applications: A comprehensive outlook from developing countries to advanced applications

Green Analytical Chemistry
In recent years, there has been a notable rise in the significance of green chemistry principles across diverse fields of chemical research, including that of analytical chemistry. This heightened focus is largely attributable to a growing awareness of environmental conditions and the detrimental impact that analytical procedures can have on the ...
S. Irem Kaya, Goksu Ozcelikay-Akyildiz, Sibel A. Ozkan   +2 more
openaire   +2 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Green Metric Assessment of Analytical Techniques for the Imidazole Prodrug Olmesartan Medoxomil: A Comparative Analysis

Critical Reviews in Analytical Chemistry
Analytical methods for Olmesartan Medoxomil (OM) have gained significant attention in pharmaceutical analysis, aligning with the green chemistry principles. Various spectroscopic and chromatographic techniques have been developed to ensure accurate, cost-effective, and environmentally friendly quantification of the OM. UV spectroscopic strategies offer
Isha Solanki, Hemant Kumar Tatapudi, Mohana Vamsi Nuli, Kumaraswamy Gandala, Lalitha Repudi   +4 more
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Spectrophotometric method development and validation for simultaneous quantification of Cefoperazone and Sulbactum sodium in bulk and marketed formulation: greenness profile evaluation

Green Analytical Chemistry
The antibiotics Cefoperazone Sodium and Sulbactam Sodium are widely employed in clinical medicine as means to combat many kinds of bacterial infections. The drugs Cefoperazone and Sulbactum shows wavelength at 229 m and 277 nm respectively in solvent of ...
Nitin Kumar, Praveen Kumar Kusuma, Bhukya Vijay Nayak, Durga Prasad Beda   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Utility of sustainable ratio derivative spectrophotometry for the concurrent assay of synergistic repurposed drugs for COVID-19 infections; Insilico pharmacokinetics proof

BMC Chemistry
The cutting-edge combination of fluvoxamine (FVM) and ivermectin (IVM) has been presented as a proposed dosage form for the treatment of COVID-19 infections in early diagnosed patients. The main objective of this work is to develop simple, sensitive, and
Sara I. Aboras, Ahmed A. Megahed, Fawzy El-Yazbi, Hadir M. Maher   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source