Results 151 to 160 of about 13,202,646 (304)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Analytical method for determining the sulfur content of EP (extreme pressure) additives in lubricating oils. [PDF]

MethodsX
Nagy R, Kolnhófer P, Nagy GZ.
europepmc   +1 more source

Control strategy applied to a LC-DAD quality control method as part of the analytical quality by design approach: one year of routine use

, 2018
The analytical quality by design approach has been previously applied to the method development. The analytical target profile (ATP) was defined as the baseline separation of the two analytes of interest, cannabidiol and Δ9-tetrahydrocannabinol.
Furlanetto, Sandra, Hubert, Cédric, Orlandini, Serena, Pasquini, Benedetta, Hubert, Philippe, Avohou, Tonakpon Hermane, Deidda, Riccardo, Baronti, Roberto   +7 more
core  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Development and validation of a green analytical method to determine bromhexine hydrochloride in pharmaceuticals. [PDF]

Sci Rep
Mohamed SK, Nour-Eldeen DA, Omar MA.
europepmc   +1 more source

Development and validation of an analytical method for the analysis of the drug product “Aciclin Crema 5%”

reservedThe aim of the study is to develop and validate an analytical method for the simultaneous determination of Acyclovir, Guanine, Methyl p-hydroxybenzoate and unknow impurities in medicinal product “Aciclin cream 5%” by HPLC (High Pressure Liquid ...
CAMPOSAMPIERO, SVEVA
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Analytical method development and validation of a serum LC-MS/MS assay for 2 emerging synthetic cannabinoids: 5F-MDMB-PICA and MDMB-4en-PINACA. [PDF]

Medicine (Baltimore)
Akbaba M, Isir AB, İbili S, Yiğitsoy CE.   +3 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Development and Optimisation of a Stability-Indicating Analytical Method for Itraconazole in Drug Product by High-Performance Liquid Chromatography Using a QbD Approach. [PDF]

Pharmaceuticals (Basel)
Fraschi-Nieto A, Mula-Roldán X, Gavaldà-Cánovas L, Mercadé-Frutos D, García-Montoya E, Suñé-Pou M, Pérez-Lozano P.   +6 more
europepmc   +1 more source