Results 211 to 220 of about 1,089,942 (311)

Trench MOS Schottky Diodes: A Physics-Based Analytical Model Approach to Charge Sharing. [PDF]

Micromachines (Basel)
Quddus MT, Latorre-Rey AD, Ramezani Z, Mudholkar M.   +3 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Ultra-Short Pulses Laser Heating of Dielectrics: A Semi-Classical Analytical Model. [PDF]

Materials (Basel)
Badea L, Duta L, Mihailescu CN, Oane M, Trefilov AMI, Popescu A, Hapenciuc C, Mahmood MA, Ticos D, Mihailescu N, Ristoscu C, Anghel SA, Mihailescu IN.   +12 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Development of Analytical Model to Describe Reflectance Spectra in Leaves with Palisade and Spongy Mesophyll. [PDF]

Plants (Basel)
Sukhova E, Zolin Y, Grebneva K, Berezina E, Bondarev O, Kior A, Popova A, Ratnitsyna D, Yudina L, Sukhov V.   +9 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Analytical Model to Deduce the Conformational and Dynamical Behavior in Dendrimers: A Review. [PDF]

Polymers (Basel)
Bhardwaj S, Kumar A.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Cerebral blood flow monitoring using a deep learning implementation of the two-layer diffuse correlation spectroscopy analytical model with a 512 × 512 SPAD array. [PDF]

Neurophotonics
Pan M, Li C, Zhang Y, Mollins A, Wang Q, Erdogan AT, Hua Y, Zang Z, Finlayson N, Henderson RK, Day-Uei Li D.   +10 more
europepmc   +1 more source

An improved analytical model for the prediction of the nonlinear behavior of flat and curved deployable space frames

, 1997
Gantes, C, Charis Gantes
core   +1 more source