FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Power Plant Waste Heat Utilization for Soil Heating using Subsurface Pipes
Journal of Engineering and Sustainable Development, 2012 Warm water is circulated through the soil medium in order to maintain the plant root zone above the same critical temperature. In power plants rejecting heat from steam through the condenser, the waste heat could be a suitable resource for soil heating.
Salah Sabeeh Abed-Alkareem
doaj
An Analytical Solution for Inverse Kinematics of SSRMS-Type Redundant Manipulators. [PDF]
Sensors (Basel), 2023 Qin L, Wei X, Lv L, Han L, Fang G.
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A Closed-Form Analytical Solution for the Axisymmetric Compression of Packer Rubber Cylinders Based on the Mooney-Rivlin Model. [PDF]
Materials (Basel)Li J +6 more
europepmc +1 more source
Theoretical study of diffusive model of HIV-1 infection and its analytical solution. [PDF]
PLoS One, 2023 Aljahdaly NH, Alharbey RA, Aljohani AS.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
An Analytical Solution for Saturable Absorption in Pharmacokinetics Models. [PDF]
Pharm Res, 2023 Sorzano COS, Moreno MAP, Vilas JL.
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source