Results 251 to 260 of about 4,694,462 (306)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Epidemic Evolution: Multiple Analytical Solutions for the SIR Model

, 2020
Lerche I.
europepmc   +1 more source

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Analytic Solutions of Systems

Journal of Dynamical and Control Systems, 2002
The authors present functional series solutions to a nonlinear analytical system for the unknown state variable, and functional series solutions to analytic infinite-dimensional linear systems. Both systems are solved by the SWSE (Summing weighted sequential error) method.
Stefanovski, J., Trenčevski, K.
openaire   +2 more sources

Coulomb expansion: Analytical solutions

Physical Review E, 2013
Exact and approximate analytical solutions are presented, describing expansion of a cloud of charged particles in one, two, and three dimensions (assuming the planar, axial, and spherical symmetries, respectively). The expansion occurs in a gas or dilute plasma, where the screening is unimportant, so that particles interact with each other via Coulomb ...
openaire   +3 more sources

Analytical Methods Of Solution

1969
The theory developed in the previous chapters shows that the study of the linearized Boltzmann equation is a worthwhile undertaking and that many of the features of its solutions can be retained by using model equations. We can say more, that practically all the features are retained by a properly chosen model.
openaire   +1 more source

Analytical Planetary solution VSOP2000

Celestial Mechanics and Dynamical Astronomy, 2001
The analytical planetary solution VSOP2000 determines the planetary perturbations with the help of an iterative method from a solution developed till the third order of the disturbing masses. This solution is from 10 to 100 times more precise than the previous analytical solutions VSOP82 and VSOP87, at the level of some 0.1 mas for Mercury, Venus and ...
Moisson, Xavier, Bretagnon, Pierre
openaire   +2 more sources

A PaaS for composite analytics solutions

Proceedings of the 12th ACM International Conference on Computing Frontiers, 2015
In their pursuit of market competitiveness and sustainable top line growth, enterprises are increasingly turning to sophisticated analytics solutions to derive insights and value from the deluge of data that are being generated from all sources. Leading practitioners of Big Data analytics have already moved past the stage of using single analytics ...
Paula Austel, Han Chen, Parijat Dube, Thomas A. Mikalsen, Isabelle Rouvellou, Upendra Sharma, Ignacio Silva-Lepe, Revathi Subramanian, Wei Tan 0001, Yandong Wang   +9 more
openaire   +1 more source