Results 91 to 100 of about 21,890 (235)

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Lipemia Interferences in Biochemical Tests, Investigating the Efficacy of Different Removal Methods in comparison with Ultracentrifugation as the Gold Standard

Journal of Analytical Methods in Chemistry, 2020
Introduction. As a common interferer in clinical chemistry, lipemic specimens could be a source of significant analytical errors. Ultracentrifugation has been by far the only reliable, but an unavailable and expensive, method to eliminate the lipemic ...
Neda Soleimani, Sahand Mohammadzadeh, Fateme Asadian   +2 more
doaj   +1 more source

Spectrum of polysaccharides degradation products of ales and lager beers [PDF]

, 2005
The saccharide spectrum, as a distribution of fractions of different molecular mass, of sixteen beers was determined by ultracentrifugation using filters with cut-offs of 1, 5, 10 and 50 kDa. The saccharide concentrations in the filtrates were determined
Claeyssens, Marc, Stals, Ingeborg, Van Landschoot, Anita, Vanderputten, Dana   +3 more
core   +1 more source

The crystal structure of superoxide dismutase from Plasmodium falciparum [PDF]

, 2006
Background: Superoxide dismutases (SODs) are important enzymes in defence against oxidative stress. In Plasmodium falciparum, they may be expected to have special significance since part of the parasite life cycle is spent in red blood cells where the ...
Boucher, Ian W., Brannigan, James A., Brzozowski, Andrzej M., Kyes, Sue A., Schnick, Claudia, Smith, Derek J., Wilkinson, Anthony J.   +6 more
core   +3 more sources

Tumor‐Associated Sympathetic Nerves Promote the Progression of Epstein‐Barr Virus‐Positive Diffuse Large B‐Cell Lymphoma

Advanced Science, EarlyView.
Sympathetic nerve innervation promotes the progression of Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV+ DLBCL) via β2‐adrenergic receptors. The discovery of enhanced nerve infiltration and β2AR expression reveals a novel mechanism and highlights the sympathetic–β2AR axis as a promising target for therapeutic intervention in EBV+ DLBCL.
Silan Huang, Dexin Lei, Linbin Yang, Aiwei Bi, Yanlou Wang, Peng Zhang, Dongyu Zhuang, Honglian Liu, Qingqing Cai, Man Nie, Yi Xia   +10 more
wiley   +1 more source

Solution‐Based Determination of Dissociation Constants for the Binding of Aβ42 to Antibodies

ChemistryOpen, 2019
Amyloid β‐peptides (Aβ) play a major role in the pathogenesis of Alzheimer's disease. Therefore, numerous monoclonal antibodies against Aβ have been developed for basic and clinical research.
Tao Zhang, Dr. Luitgard Nagel‐Steger, Prof. Dr. Dieter Willbold   +2 more
doaj   +1 more source

Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein

, 2020
The ATP-dependent Hsp70 chaperones (DnaK in E. coli) mediate protein folding in cooperation with J proteins and nucleotide exchange factors (E. coli DnaJ and GrpE, respectively). The Hsp70 system prevents protein aggregation and increases folding yields.
Balchin, D., Hartl, F., Hayer-Hartl, M., Imamoglu, R.   +3 more
core   +1 more source

HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface [PDF]

, 2004
Transferrin receptor (TfR) is a dimeric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE, the protein mutated in patients with the iron overload disorder hereditary hemochromatosis.
Bjorkman, Pamela J., Giannetti, Anthony M.   +1 more
core   +2 more sources

Analytical ultracentrifugation for analysis of doxorubicin loaded liposomes

International Journal of Pharmaceutics, 2017
Analytical ultracentrifugation (AUC) is a powerful tool for the study of particle size distributions and interactions with high accuracy and resolution. In this work, we show how the analysis of sedimentation velocity data from the AUC can be used to characterize nanocarrier drug delivery systems used in nanomedicine.
Mehn, Dora, Iavicoli, Patrizia, Cabaleiro, Noelia, Borgos, Sven Even, Caputo, Fanny, Geiss, Otmar, Calzolai, Luigi, Rossi, François, Gilliland, Douglas   +8 more
openaire   +3 more sources