Results 131 to 140 of about 21,890 (235)

High‐Throughput MicroED for Probing Ion Channel Dynamics

Advanced Science, EarlyView.
High‐throughput MicroED offers a new approach for visualizing ion channel dynamics. This approach reveals NaK’s sodium binding modes and NaK2CNG’s potassium‐induced selectivity filter dilation and gating. By capturing these distinct structures, this work challenges traditional models of ion channel permeation and selectivity. Abstract Ion channels play
Marc J Gallenito, Max TB Clabbers, Jieye Lin, Johan Hattne, Tamir Gonen   +4 more
wiley   +1 more source

Engineered Bacterial Outer Membrane Vesicles Hitchhiking on Neutrophils for Antibody Drug Delivery to Enhance Postoperative Immune Checkpoint Therapy

Advanced Science, EarlyView.
This study employs neutrophils for the precise delivery of anti‐CD47 antibodies, combined with bacterial outer membrane vesicles, to enhance macrophage phagocytic function in the tumor microenvironment. This approach effectively activates T‐cell anti‐tumor immune responses and significantly reduces the risk of postoperative tumor recurrence and ...
Meng Guan, Xiao‐Ting Xie, Dong Zhou, Kai Cheng, Bin Zhang, Xin‐Yue Xu, Yong Li, Yi‐Tong Zhou, Wei Peng, Li‐Li Chen, Peng‐Shuo Dong, Si Chen, Jia‐Hua Zou, Bo Liu, Yuan‐Di Zhao, Jin‐Xuan Fan   +15 more
wiley   +1 more source

Characterization of plasma low density lipoproteins on nonhuman primates fed dietary cholesterol1

Journal of Lipid Research, 1977
LDL from animals of three nonhuman primate species, Macaca mulatta, Macaca fascicularis, and Cercopithecus aethiops, were studied. A standard preparation of 125I-LDL was added to isolated lipoprotein mixtures just prior to separation of plasma ...
L L Rudel, L L Pitts, 2nd, C A Nelson
doaj  

Tβ4‐Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing

Advanced Science, EarlyView.
A separable microneedle patch is designed for Tβ4–modified ADSC‐derived extracellular vesicles delivery. The overexpressed Tβ4 released from the microneedles can mitigate cellular senescence and promote wound healing via the PTEN/PI3K/AKT pathway, offering a promising approach for diabetic wound treatment. This bioengineered therapeutic system serve as
Youjun Ding, Jinglin Wang, Jiaye Li, Yi Cheng, Shuyin Zhou, Yepeng Zhang, Yuanjin Zhao, Min Zhou   +7 more
wiley   +1 more source

Enhancing Chemotherapy‐Related Immune Responses via Bioorthogonal Metabolic Engineering‐Driven Tumor Exosomes Elimination

Advanced Science, EarlyView.
In this work, a novel strategy named bioorthogonal reaction‐driven exosome elimination (Biordee) strategy was developed to inhibit chemotherapy‐associated breast cancer metastasis and enhance the immune response. Biordee possessed the capacity of in‐situ editing tumor‐derived exosomes (TExo) with IgG Fc and promoted macrophage phagocytosis of ...
Wentao Zhang, Tianyi Yang, Tian Jin, Tianyi Zhu, Fang Hao, Miao Fan, Yanrong Zhang   +6 more
wiley   +1 more source

Multimode chromatography‐based techniques for high purity isolation of extracellular vesicles from human blood plasma

Journal of Extracellular Biology
Extracellular vesicles (EVs) play a pivotal role in various biological pathways, such as immune responses and the progression of diseases, including cancer.
Alan J. Zimmerman, Getulio Pereira deOliveira Jr., Xianyi Su, Jacqueline Wood, Zhengxin Fu, Brandy Pinckney, John Tigges, Ionita Ghiran, Alexander R. Ivanov   +8 more
doaj   +1 more source

Impact of Virus‐Mediated Modifications in Bacterial Communities on the Accumulation of Soil Organic Carbon

Advanced Science, EarlyView.
This study illustrates the impact of viruses on carbon cycling in soils with different availabilities of carbon. In conditions of low carbon availability, viruses adopt a lysogenic lifestyle, integrate into the host genomes and facilitate the degradation of carbon.
Mingfeng Liu, Guixiang Zhou, Congzhi Zhang, Lin Chen, Donghao Ma, Lijun Zhang, Chunhua Jia, Ling Ma, Jiabao Zhang   +8 more
wiley   +1 more source

Structures of Polyhydroxyalkanoate Synthase PhaC from Aeromonas caviae, Producing Biodegradable Plastics

Angewandte Chemie, EarlyView.
PHA synthase (PhaC) is the key enzyme in the polymerization of a biodegradable plastic—polyhydroxyalkanoate (PHA). Structures of full‐length PhaC reveal three key regions essential for substrate specificity and polymerization. Additionally, this study also highlights the critical role of N‐domain‐dependent dimerization in PhaC activity.
Min Fey Chek, Sun‐Yong Kim, Tomoyuki Mori, Keiji Matsumoto, Shunsuke Sato, Toshio Hakoshima   +5 more
wiley   +2 more sources

A Nano‐Electro‐Platform Enabling Evolutionary Screening and Remodeling of Tumor Cells for Metastasis Inhibition

Advanced Science, EarlyView.
The nano‐electro‐platform achieves non‐destructive evolutionary screening and electro‐remodeling of tumor cells to generate extracellular vesicles with enhanced tumor‐targeting and therapeutic functions. These extracellular vesicles demonstrate remarkable efficacy in activating both macrophages and T cells, thereby orchestrating a potent immune ...
Feng Liu, Hong Sun, Bing Liu, Jing Zhang, Chengbao Wu, Shi Yan, Chengzheng Tai, Yihang Tong, Rongtai Su, Xiaowei Xiang, Han Wu, Fuqi Yao, Kuan Yang, Dedong Yin, Yuqiong Wang, Ao Xiao, Long Cheng, Xi Chen, Nan Wu, Zaizai Dong, Lingqian Chang   +20 more
wiley   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun‐Xia Zhao, Yun Liu   +5 more
wiley   +1 more source