Results 161 to 170 of about 21,890 (235)

Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin

Cytoskeleton, EarlyView.
ABSTRACT Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed‐end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates at barbed versus pointed ends.
Sawako Yamashiro, Shashank Shekhar, Stefanie M. Novak, Sudipta Biswas, Carol C. Gregorio, Velia M. Fowler   +5 more
wiley   +1 more source

Tethering Efficiency of Reversible Addition‐Fragmentation Chain Transfer‐Synthesized Styrene Maleic Acid Polymers and Associated Styrene Maleic Acid Lipid Nanoparticles on Gold Surfaces

ChemPlusChem, EarlyView.
Styrene maleic acid lipid nanoparticles (SMALPs) comprised of diblock styrene maleic acid (SMA) copolymers readily tether to gold surfaces. This binding is enhanced when the diblock SMA is functionalized with a trithiocarbonate and hydrophilic (Z)‐end‐group generated through the reversible addition‐fragmentation chain transfer polymerization process ...
Michelle D. Farrelly, Denis Korneev, Lisandra L. Martin, San H. Thang   +3 more
wiley   +1 more source

Enhanced Separation of Extracellular Vesicles Using Capillary Isotachophoresis With Spacer Compounds

ELECTROPHORESIS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are pivotal in numerous physiological and pathological processes, such as immune responses, viral pathogenesis, pregnancy, cardiovascular diseases, and cancer progression. Their capacity to influence complex intracellular pathways highlights their therapeutic potential in addressing various conditions, including ...
Milan Pieter Paul de Putter, Andrea Capuano, Meia Numan, Thomas Hankemeier, Yuliya Shakalisava   +4 more
wiley   +1 more source

Defining the interaction of the protease CpaA with its type II secretion chaperone CpaB and its contribution to virulence in Acinetobacter species [PDF]

, 2017
Feldman, Mario F., Kinsella, Rachel L., Lopez, Juvenal, Palmer, Lauren D., Salinas, Nichole D., Skaar, Eric P., Tolia, Niraj H.   +6 more
core   +2 more sources

Immunomodulatory Nanozymes Eradicate Intracellular Infections and Rescue Immunoparalysis for Treating Multidrug‐Resistant Bacterial Sepsis

Exploration, EarlyView.
Immunomodulatory nanozymes enable in situ macrophages engineering and orchestrate systemic innate‐adaptive immune response to eradicate intracellular bacteria and rescue immunoparalysis for treating multidrug‐resistant bacterial sepsis. ABSTRACT Sepsis and their sequelae are the leading causes of death in intensive care units, with limited therapeutic ...
Xuancheng Du, Zhenzhen Dong, Yan Yan, Yuan Gong, Meili Yuan, Chengtai Ma, Lingqi Xu, Yuanyuan Qu, Minhan Qu, Peng Pan, Weifeng Li, Wenyan Hao, Yingyi Yang, Xiangdong Liu, Mingwen Zhao, Zhenjiang Bai, Jiang Huai Wang, Jian Wang, Yong‐Qiang Li, Huiting Zhou   +19 more
wiley   +1 more source

Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology

Glia, EarlyView.
In a pre‐symptomatic mouse model of Alzheimer disease, despite higher amyloid‐β load, females display fewer plaques than males. More efficient synaptic transmission as well as less microgliosis point to better early coping with pathogenesis in females.
Thomas Chaigneau, Sha Sha, Candice M. Roux, Saba Aïd, Alice Faucher, Yannick Chantran, Guillaume Dorothée, Slavica Krantic   +7 more
wiley   +1 more source

A promising frontier of circulating messenger RNA in liquid biopsy: From mechanisms to clinical applications

International Journal of Cancer, EarlyView.
Abstract Liquid biopsy can revolutionize cancer patient management as repeated sampling allows real‐time monitoring of disease progression and response to treatment. The circulating transcriptome represents a rich source of potential cancer biomarkers, including coding and non‐coding RNAs.
Mengqian Li, Yijin Yu, Guangyue Liu, Shunhong Zhang, Chenchen Luo, Saidi Hu, Siran Wan, Linyong Zhao   +7 more
wiley   +1 more source

C, N and noble gases in different pH and grain size fractions of pre-solar diamonds from Boriskino chondrite [PDF]

, 2001
Fisenko, A. V., Pillinger, C. T., Semenova, L. F., Verchovsky, A. B., Wright, I. P.   +4 more
core  

Construction of Reporter Phage T4::Nluc and Its Application in the Detection of Escherichia coli in Urinary Tract Infections

iLABMED, EarlyView.
A reporter phage T4::Nluc was constructed using the CRISPR/Cas9 system combined with homologous recombination and was applied for the detection of clinical Escherichia coli in urinary tract infections (UTIs). T4::Nluc exhibited superior sensitivity and specificity, and had a short detection time, making it a powerful tool for diagnosing UTIs.
Zhiyun Hao, Minwei Li, Qiang Zhao, Liye Wang, Ting Liu, Chi Wang, Chengbin Wang   +6 more
wiley   +1 more source

Organoid‐tissue extracellular vesicles

Interdisciplinary Medicine, EarlyView.
Abstract Extracellular vesicles (EVs) are lipid bilayer structures secreted by cells that act as intercellular messengers. Tissue‐derived EVs (TEVs), harvested from the tissue interstitium, directly reflect the actual physiological or pathological state of the tissue microenvironment.
Han Liu, Ting Cheng, Guangfeng Li, Zhidao Xia, Chenglong Wang, Ke Xu, Jiacan Su   +6 more
wiley   +1 more source