Results 181 to 190 of about 21,890 (235)
Small, EarlyView.The perspective highlights how advanced analytical and computational tools—from batch tests and isotope labeling to in situ Electron Microscopy and Artificial IntelligenceI/Machine Learning—enable a deeper understanding of Engineered nanomaterial dissolution. These insights are crucial for controlling, regulating, and leveraging dissolution dynamics to
Swaroop Chakraborty +2 more
wiley +1 more source
Small, EarlyView.This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai +5 more
wiley +1 more source
Small Science, EarlyView.A modular hybrid membrane is constructed via a layer‐by‐layer strategy, integrating glucose oxidase/horseradish peroxidase or glucose oxidase/nanozyme‐loaded microreactors within alternating polyelectrolyte layers on a calcium carbonate core. This hierarchical design enables precise spatial confinement of catalytic units, facilitating efficient cascade
Aitor Ontoria +7 more
wiley +1 more source
Enhanced Discriminability of Viral Vectors in Viscous Nanopores
Small Methods, EarlyView.Solid‐state nanopore sensing in high‐viscosity organic‐water mixture enables enhanced discriminability of full, intermediate, and empty AAV vectors at the single particle level, paving the way for enhanced quality control of AAV products for their wide applications in gene therapy.
Makusu Tsutsui +9 more
wiley +1 more source
Small Methods, EarlyView.Analytical ultracentrifugation (AUC) is a powerful tool for studying the size–property relationships of nanomaterials in their native environment. A methodology based on AUC with in‐line multiwavelength emission detection is developed, enabling the measurement of the size‐resolved emission spectra of giant‐shell CdSe/CdS quantum dots.
Lisa M. S. Stiegler +5 more
wiley +1 more source
Small Methods, EarlyView.This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta +7 more
wiley +1 more source
Nanoplasmonic Sensing of Heterogeneous Extracellular Vesicles: From Bulk to Single Vesicles
Small Methods, EarlyView.Extracellular vesicles (EVs) are highly heterogeneous nanoscale blood biomarkers. With their tunable implementations, nanoplasmonic platforms can capture myriad vesicular information via scalable bulk analyses of EV biomarkers or high‐resolution single‐vesicle measurements.
Yan Zhang, Chao Wang, Huilin Shao
wiley +1 more source
Modeling Conformational and Molecular Weight Heterogeneity with Analytical Ultracentrifugation Experiments [PDF]
, 2008 Brookes, E., Demeler, B.
core
Small Methods, EarlyView.This study presents a rapid and sensitive virus detection method that employs imaging of virus‐specific DNA markers. Utilizing specially designed single‐stranded circular DNA probes, this method captures RNA fragments from RNase‐digested viral genomes during the reverse transcriptase‐based reaction, resulting in double‐stranded markers that are ...
Yoon‐ha Jang +13 more
wiley +1 more source
Hyperspectral Raman imaging to understand patterns in dried biofluids in Alzheimer's disease
VIEW, EarlyView.Raman spectroscopy is commonly used to identify biomarkers in biological fluids, often focusing on the outer ring of dried droplets due to molecular accumulation from the coffee ring effect. However, this approach may overlook important spectral information, so hyperspectral Raman mapping is used to analyze the entire droplet and identify optimal ...
Eneko Lopez +8 more
wiley +1 more source