Results 191 to 200 of about 21,890 (235)

Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles

Aging Cell, EarlyView.
A senomorphic miRNA cocktail (E5), consisting of miR‐181a‐5p, miR‐92a‐3p, miR‐21‐5p, and miR‐186‐5p, was identified from a pool of miRNAs enriched in extracellular vesicles (EVs) derived from multiple functional human stem cell types. E5 reduces senescence and SASP markers both in cell culture and in aged mice.
Tianpeng Zhang, Allancer D. C. Nunes, Jieun Lee, Dana Larocca, Giovanni Camussi, Sai Kiang Lim, Vicky U. Bascones, Luise Angelini, Ryan D. O'Kelly, Xiao Dong, Laura J. Niedernhofer, Paul D. Robbins   +11 more
wiley   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

Opportunistic sampling from the near‐threatened Alexandrine parakeet uncovers genomes of a novel parvovirus and beak and feather disease virus

Australian Veterinary Journal, EarlyView.
Birds are known to harbour a wide range of pathogenic viruses, including the beak and feather disease virus (BFDV; species, Circovirus parrot), which poses a significant threat to the conservation of endangered avian species. This study reports the genomic identification and characterisation of a novel psittaciform chaphamaparvovirus (PsChPV‐6) and ...
S Sarker, N Klukowski, S Talukder, A Athukorala, MJ Uddin   +4 more
wiley   +1 more source

Structural Information on Supramolecular Copper(II) β‑Diketonate Complexes from Atomic Force Microscopy and Analytical Ultracentrifugation

ACS Omega
Jonathan S. Casey, Ashley R. Walker, Xianglin Zhai, Jayne C. Garno, Paul S. Russo, Andrew W. Maverick   +5 more
doaj   +1 more source

Ellagic Acid‐Loaded sEVs Encapsulated in GelMA Hydrogel Accelerate Diabetic Wound Healing by Activating EGFR on Skin Repair Cells

Cell Proliferation, EarlyView.
Ellagic acid (EA) was loaded in small extracellular vehicles (sEVs) derived from chorionic plate‐mesenchymal stem cells (CP‐MSCs) and then encapsulated in GelMA to construct Gel‐EA‐sEVs, which can be a promising treatment approach for diabetic wounds by improving biological functions of skin repair cells.
Lige Tian, Zihao Wang, Shengqiu Chen, Kailu Guo, Yaying Hao, Liqian Ma, Kui Ma, Junli Chen, Xi Liu, Linlin Li, Xiaobing Fu, Cuiping Zhang   +11 more
wiley   +1 more source

Mechanism of EC‐EXOs‐Derived THBS3 Targeting CD47 to Regulate BMSCs Differentiation to Ameliorate Bone Loss

Cell Proliferation, EarlyView.
EC‐EXOs could regulate the differentiation of BMSCs through the key protein THBS3, which inhibits their differentiation to lipogenic cells and promotes their differentiation to osteoblasts. THBS3 could down‐regulate the expression of its downstream target CD47 and delay the process of bone loss in aged mice and OVX mice, which may provide a novel ...
Jiaojiao Wang, Zhaokai Zhou, Wenjie Chen, Yun Chen, Qiyue Zheng, Yajun Chen, Zhengxiao Ouyang, Ran Xu, Qiong Lu   +8 more
wiley   +1 more source

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Calibrating analytical ultracentrifuges

European Biophysics Journal, 2021
Analytical ultracentrifugation (AUC) is based on the concept of recording and analyzing macroscopic macromolecular redistribution that results from a centrifugal force acting on the mass of suspended macromolecules in solution. Since AUC rests on first principles, it can provide an absolute measurement of macromolecular mass, sedimentation and ...
Huaying Zhao, Ai Nguyen, Samuel C. To, Peter Schuck   +3 more
openaire   +3 more sources

MODERN APPLICATIONS OF ANALYTICAL ULTRACENTRIFUGATION

Annual Review of Biophysics and Biomolecular Structure, 1999
Analytical ultracentrifugation is a classical method of biochemistry and molecular biology. Because it is a primary technique, sedimentation can provide first-principle hydrodynamic and first-principle thermodynamic information for nearly any molecule, in a wide range of solvents and over a wide range of solute concentrations. For many questions, it is
Laue, Thomas M., Stafford, Walter F., III   +1 more
openaire   +3 more sources

Pseudoisokinetic analytical ultracentrifugation: Monitoring of bands at a fixed region in the analytical ultracentrifuge

Analytical Biochemistry, 1978
Abstract With the use of a Model E analytical ultracentrifuge equipped with a photoelectric scanner, a technique for obtaining isokinetic patterns of moving zones has been developed by monitoring a fixed area of the analytical cell as a function of time. Small amounts of material spread over a very wide range of sedimentation coefficients can be used
Sidney Pestka, Daniel Luk
openaire   +3 more sources

Analytical Ultracentrifugation

Current Protocols in Protein Science, 1996
AbstractAnalytical ultracentrifugation is one of the most powerful, though as yet underexploited, techniques available to molecular biology and biochemistry. This overview describes applications for analytical ultracentrifugation along with important considerations relating to experimental design.
openaire   +4 more sources