Results 51 to 60 of about 21,890 (235)

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Molecular interactions between complement factor H and its heparin and heparan sulphate ligands

Frontiers in Immunology, 2014
Complement Factor H (CFH) is the major regulator of the central complement protein C3b in the alternative pathway of complement activation. A molecular view of the CFH interaction with native heparan sulphate is central for understanding the mechanism ...
Stephen John Perkins, Ka Wai eFung, Sanaullah eKhan   +2 more
doaj   +1 more source

Separation of specific single-enantiomer single-wall carbon nanotubes in the large-diameter regime [PDF]

, 2019
The enantiomer-level isolation of single-walled carbon nanotubes (SWCNTs) in high concentration and with high purity for nanotubes greater than 1.1 nm in diameter is demonstrated using a two-stage aqueous two-phase extraction (ATPE) technique.
Cambré, Sofie, Dehm, Simone, Garrity, Oisin, Gordeev, Georgy, Krupke, Ralph, Li, Han, Peyyety, Naga Anirudh, Reich, Stephanie, Selvasundaram, Pranauv Balaji, Wenseleers, Wim [u.v.m.]   +9 more
core   +1 more source

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly [PDF]

, 2011
The final version of this article is available at the link below.Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine comprising multiple copies of three distinct enzymes (E1–E3) and an
Alan Cooper, Blass, Brautigam, Brautigam, Chamberlain, Ciszak, Cooper, David Gilbert, Donna P. McGow, Frank, Hipps, Hiromasa, Hodgson, Hoyer, Huang, Izard, J. Gordon Lindsay, Jones, Jung, Konarev, Laue, Lessard, Leung, Lynch, Mande, Margaret A. Nutley, Mayers, McCartney, Olwyn Byron, Peter Kropholler, Philip Callow, Robinson, Sanderson, Schuck, Semenyuk, Smolle, Stanley, Stoops, Svergun, Swetha Vijayakrishnan, Vijayakrishnan, Wagenknecht, Yu, Zhou, Zhou   +44 more
core   +3 more sources

Bacteria‐Derived Extracellular Vesicle as A “Trojan Horse” for Selective M1 Macrophage‐Targeting in A Multi‐Cellular Entanglement Environment

Advanced Functional Materials, EarlyView.
The temporary transition of macrophages from a pro‐inflammatory phenotype of macrophages (M1) to an anti‐inflammatory phenotype of macrophages (M2) is crucial for tissue repair and regeneration processes. Bacterial outer membrane vesicles (OMVs) are utilized as a “trojan horse” for specific M1 macrophage‐targeting and anti‐inflammatory drug delivery ...
Donglin Cai, Zhelun Li, Wendong Gao, Yuqing Mu, Jiaying Liu, Yufeng Zhang, Xiaohan Mei, Jingjing Quan, Lan Xiao, Yin Xiao   +9 more
wiley   +1 more source

Characterisation of mass distributions of solvent-fractionated lignins using analytical ultracentrifugation and size exclusion chromatography methods

Scientific Reports, 2021
Lignins are valuable renewable resources for the potential production of a large array of biofuels, aromatic chemicals and biopolymers. Yet native and industrial lignins are complex, highly branched and heterogenous macromolecules, properties that have ...
Yudong Lu, Lionard Joosten, Jacqueline Donkers, Fabrizio Andriulo, Ted M. Slaghek, Mary K. Phillips-Jones, Richard J. A. Gosselink, Stephen E. Harding   +7 more
doaj   +1 more source

Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression [PDF]

, 2015
In a wide variety of bacterial restriction–modification systems, a regulatory `controller' protein (or C-protein) is required for effective transcription of its own gene and for transcription of the endonuclease gene found on the same operon.
Kneale, G. G., Mcgeehan, J. E., Shevtsov, M. B., Streeter, S. D., Swiderska, A., Thresh, S.-J.   +5 more
core   +2 more sources

Analytical ultracentrifugation in structural biology [PDF]

Biophysical Reviews, 2017
Researchers in the field of structural biology, especially X-ray crystallography and protein nuclear magnetic resonance, are interested in knowing as much as possible about the state of their target protein in solution. Not only is this knowledge relevant to studies of biological function, it also facilitates determination of a protein structure using ...
openaire   +3 more sources

1D Light‐Emitting MAPbBr3 Perovskite Encapsulated in Carbon Nanotubes

Advanced Functional Materials, EarlyView.
Encapsulation of MAPbBr3 perovskite in single‐walled carbon nanotubes (SWCNTs) yields a hybrid nanomaterial with distinctive optoelectronic properties. Perovskite confinement induces a unified single‐peak photoluminescence (PL) with a reduced lifetime, while charge transfer alters the optical properties of nanotubes.
Valentina A. Eremina, Timofei Eremin, Hua Jiang, Rakesh Dhama, Jokotadeola Odutola, Humeyra Caglayan, Nikolai V. Tkachenko, Petr A. Obraztsov   +7 more
wiley   +1 more source