Results 71 to 80 of about 21,890 (235)
Advanced Healthcare Materials, EarlyView.CLDN18.2 CAR‐T cell‐derived small extracellular vesicles (CAR‐sEVs) display potent cytotoxicity and prolong survival in preclinical pancreatic cancer models. They contain functional CAR proteins and granzyme B, exhibit antigen specificity, and effectively target tumor cells while sparing healthy cells.
Yue Qing +7 more
wiley +1 more source
VirusesThe enterovirus A71 (EV71) inactivated vaccine is an effective intervention to control the spread of the virus and prevent EV71-associated hand, foot, and mouth disease (HFMD). It is widely administered to infants and children in China.
Anna Yang +14 more
doaj +1 more source
Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells
Advanced Healthcare Materials, EarlyView.Cell membrane nanoparticles made with stromal cells are prepared and used to target leukemia cells. Deposition of the cell membrane onto rigid silica cores leads to increased uptake both in leukemia cell lines and primary cells from patients. These results show that nanoparticle rigidity affects the interaction between cell membrane nanoparticles and ...
Sander de Weerd +8 more
wiley +1 more source
VirusesRecombinant adeno-associated viruses (rAAVs) play a pivotal role in the treatment of genetic diseases. However, current production and purification processes yield AAV-based preparations that often contain unwanted empty, partially filled or damaged ...
Mojca Janc +10 more
doaj +1 more source
Analytical band centrifugation for the separation and quantification of empty and full AAV particles
Molecular Therapy: Methods & Clinical Development, 2021 Analytical band centrifugation (ABC) was first developed for the separation of macromolecules in centrifugation cells ~60 years ago. Since its development, ABC has been predominantly utilized to study macromolecular interactions or chemical reactions ...
Harshit Khasa +3 more
doaj
Biophysical characterization of the outer membrane polysaccharide export protein and the polysaccharide co-polymerase protein from Xanthomonas campestris [PDF]
, 2014 This study investigated the structural and biophysical characteristics of GumB and GumC, two Xanthomonas campestris membrane proteins that are involved in xanthan biosynthesis. Xanthan is an exopolysaccharide that is thought to be a virulence factor that
Bianco, María Isabel +5 more
core +1 more source
Albumin Corona Overturns Long‐Acting Behaviors of Myristic Acid‐Conjugated Quetiapine Nanosuspension
Advanced Healthcare Materials, EarlyView.Albumin corona alters surface properties and enhances colloidal stability by overturning pH responsiveness and nano‐aggregation behaviors of long‐acting myristic acid‐conjugated quetiapine nanosuspensions (QMN), resulting in accelerated in vitro and in vivo drug release.
Hy Dinh Nguyen +2 more
wiley +1 more source
PLoS ONE, 2023 Extracellular vesicles (EVs) isolated from plasma are increasingly recognized as promising circulating biomarkers for disease discovery and progression, as well as for therapeutic drug delivery.
Valentina Bettio +17 more
doaj +1 more source
Accounting for thermodynamic non-ideality in the Guinier region of small-angle scattering data of proteins [PDF]
, 2016 Hydrodynamic studies of the solution properties of proteins and other biological macromolecules are often hard to interpret when the sample is present at a reasonably concentrated solution.
BH Zimm +7 more
core +2 more sources
Advanced Materials, EarlyView.Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll +16 more
wiley +1 more source