Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Knowledge, trust attitudes, and behaviors towards AI and their association with critical thinking disposition in Chinese undergraduate medical students: a cross-sectional study. [PDF]
Ma S +5 more
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CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
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An empirical study of the BOPPPS teaching model in standardized training for vascular surgery residents: teaching of diabetic foot Wagner classification and surgical intervention strategies. [PDF]
Liu D, Guo J, Guo L.
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Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
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How does task complexity and task difficulty affect college students' writing performance? The mediating effect of critical thinking disposition. [PDF]
Zou Y, Kuek F, Cheng X, Feng W.
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Critical thinking disposition of medical students in Anhui Province, China: a cross-sectional investigation. [PDF]
Zhai J, Zhang H.
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Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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