Results 51 to 60 of about 121 (120)

A Model of Strategic Sustainable Investment

open access: yesMathematical Finance, EarlyView.
ABSTRACT We study a problem of optimal irreversible investment and emission reduction formulated as a nonzero‐sum dynamic game between an investor with environmental preferences and a firm. The game is set in continuous‐time on an infinite‐time horizon.
Tiziano De Angelis   +2 more
wiley   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti   +2 more
wiley   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni   +2 more
wiley   +1 more source

Utility of local capillary supply indices: Insights from computational image‐based modelling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Local capillary distribution and fibre geometry influence oxygen availability in skeletal muscle. Image‐based modelling of tissue PO2${{P}_{{{{\mathrm{O}}}_2}}}$ shows that area‐based measures of capillary supply – the local capillary density (LCDi) and local maximum diffusion distance (Dmax,i) – most accurately represent the ...
Abdullah A. Al‐Shammari   +6 more
wiley   +1 more source

Unveiling the role of the venous system in arterial hypertension: A computational study

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This abstract figure summarizes the principal findings of our computational analysis of hypertension. Model‐based results identify reduced venous compliance as a major determinant of elevated arterial pressure, second only to increased peripheral resistance.
Eleuterio F. Toro   +4 more
wiley   +1 more source

Effect of HBr on Explosion Limits of Stoichiometric Hydrogen‐oxygen Mixture

open access: yesInternational Journal of Chemical Kinetics, Volume 58, Issue 9, Page 646-657, September 2026.
ABSTRACT This work, based on numerical simulations, discusses the effect of HBr as an inhibitor on the explosion limit of stoichiometric hydrogen‐oxygen gas mixture in a closed spherical vessel. The numerical simulation solves the complete governing equations for mass, momentum, species and energy.
Chunkan Yu, Peter Glarborg
wiley   +1 more source

A Semi‐Discrete Lagrangian‐Eulerian Numerical Scheme for Diffusive‐Dispersive Conservation Laws With Discontinuous Coefficient

open access: yesNumerical Methods for Partial Differential Equations, Volume 42, Issue 5, September 2026.
ABSTRACT In this work, we present an extension of the semi‐discrete Lagrangian‐Eulerian numerical scheme for diffusive‐dispersive conservation law problems, including a jump discontinuous flux function. As in the one‐dimensional scalar hyperbolic case, the no‐flow curves also organize the geometry of the method.
Eduardo Abreu   +2 more
wiley   +1 more source

Toward Robust Optimal Control of Chromatographic Separation Processes With Controlled Flow Reversal

open access: yesProceedings in Applied Mathematics and Mechanics, Volume 26, Issue 3, September 2026.
ABSTRACT Column liquid chromatography is an important technique applied in the production of biopharmaceuticals, specifically for the separation of biological macromolecules such as proteins. When setting up process conditions, it is crucial that the purity of the product is sufficiently high, even in the presence of perturbations in the process ...
Dominik H. Cebulla   +2 more
wiley   +1 more source

Adaptive Matrix‐Free Simulations of Fluid‐Filled Phase‐Field Fractures With Fixed‐Stress Coupling and Fracture‐Width Computation

open access: yesInternational Journal for Numerical Methods in Engineering, Volume 127, Issue 15, 15 August 2026.
ABSTRACT Fluid‐filled phase‐field fracture simulations require robust, scalable solvers that can handle strongly nonlinear, non‐smooth mechanics and tightly coupled flow on locally refined meshes. In this work, we develop an adaptive finite element framework for quasi‐static, fluid‐filled phase‐field fractures that combines semi‐smooth Newton methods ...
Leon M. Kolditz   +3 more
wiley   +1 more source

Inductive Differential Constraint Method: Symbolic Regression‐Based Partial Differential Equation Regularization for Fatigue Crack Growth Prediction

open access: yesInternational Journal for Numerical Methods in Engineering, Volume 127, Issue 15, 15 August 2026.
ABSTRACT This study introduces the inductive differential constraint method (IDCM), a data‐informed structural regularization framework that enhances neural network predictions under data‐scarce regimes by enforcing invariant differential structures extracted from simulation data.
Rekisei Ozawa, Yoshitaka Wada
wiley   +1 more source

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