Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
The Analytical Perspective of Aristotle’s Categorical and Modal Syllogisms
Peitho, 2018 What is meant under the genuine title of Aristotle’s ta Analytika is rarely properly understood. Presumably, his analytics was inspired by the method of geometric analysis.
Marian Andrzej Wesoły
doaj +1 more source
Dust size distributions in coagulation/fragmentation equilibrium: numerical solutions and analytical fits [PDF]
, 2010 T. Birnstiel +2 more
openalex +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Editorial: Using Evidence Based Analytics to Create Narratives for Police Decision Making
Frontiers in Psychology, 2021 Leslie W. Kennedy +6 more
doaj +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Design thinking: in the labyrinth of the concept
АрхитектонThe article presents a critical analysis of the most common approaches to defining the concept of «design thinking» in Russian-language publications: a creative rather than analytical method for solving any problems; focus on the interests of the end ...
Kuzmina Anastasia A. +1 more
doaj +1 more source
What-if analysis: A visual analytics approach to Information Retrieval evaluation [PDF]
, 2016 This paper focuses on the innovative visual analytics approach realized by the Visual Analytics Tool for Experimental Evaluation (VATE2) system, which eases and makes more effective the experimental evaluation process by introducing the what-if analysis.
Angelini, Marco +3 more
core
Microplastics in soils: a review of possible sources, analytical methods and ecological impacts
, 2020 Bin Zhang +5 more
openalex +2 more sources