Results 121 to 130 of about 2,985,531 (342)
Purification tags markedly affect self‐aggregation of CPEB3
FEBS Letters, EarlyView.Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Oracle Exalytics: Engineered for Speed-of-Thought Analytics [PDF]
Database Systems Journal, 2011 One of the biggest product announcements at 2011's Oracle OpenWorld user conference was Oracle Exalytics In-Memory Machine, the latest addition to the "Exa"-branded suite of Oracle-Sun engineered software-hardware systems.
Gabriela GLIGOR, Silviu TEODORU
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A Treatise on the Analytic Geometry of Three Dimensions. By G. Salmon. Fifth Edition. Revised by R. A. P Rogers. Vol. II. Pp. xvi + 334. 7s. 6d. net. 1915. (Longmans, Green.) [PDF]
, 1915 Maebh Long
openalex +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source
A Treatise on the Analytical Dynamics of Particles and Rigid Bodies; with an Introduction to the Problem of Three Bodies. By E. T. Whittaker. Second Edition. Cambridge: University Press, 1917. Pp. xii, 432. Price 15s. net. [PDF]
, 1917 Philip E. B. Jourdain
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Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Data Science as an Innovation Challenge: From Big Data to Value Proposition
Technology Innovation Management Review, 2018 Analyzing “big data” holds huge potential for generating business value. The ongoing advancement of tools and technology over recent years has created a new ecosystem full of opportunities for data-driven innovation.
Victoria Kayser +2 more
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