Results 121 to 130 of about 1,278,043 (329)

A Comprehensive and Effective Framework for Traffic Congestion Problem Based on the Integration of IoT and Data Analytics [PDF]

, 2022
Yazed Alsaawy, Ahmad B. Alkhodre, Adnan Abi Sen, Abdullah Alshanqiti, Wasim Ahmad Bhat, Nour Mahmoud Bahbouh   +5 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Empowering EDTECH Platforms

ACROSS
Analytics and AI innovations have the potential to help the decision-making processes and to bring more business opportunities for stakeholders. This study explored how analytics and AI support decision-making in EdTech platforms.
Marian STAN, Mihai CIOBOTEA, Tudor URSEIU   +2 more
doaj   +2 more sources

Edge IoT Prototyping Using Model-Driven Representations: A Use Case for Smart Agriculture

Sensors
Industry 4.0 is positioned at the junction of different disciplines, aiming to re-engineer processes and improve effectiveness and efficiency. It is taking over many industries whose traditional practices are being disrupted by advances in technology and
Ivan Guevara, Stephen Ryan, Amandeep Singh, Colm Brandon, Tiziana Margaria   +4 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Pre-analytical stability of serum biomarkers for neurological disease: neurofilament-light, glial fibrillary acidic protein and contactin-1

, 2022
Zoë YGJ van Lierop, Inge M.W. Verberk, Kees W. J. van Uffelen, Marleen J.A. Koel‐Simmelink, Lisanne in ‘t Veld, Joep Killestein, Charlotte E. Teunissen   +6 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Differences in determination of chemical elements in soil and attic dust samples due to various acid treatments, Slovenia

Geologija, 2003
The paper gives an assessment of relationship existing between analytical values of samples, which were treated with two different acid procedures: four acid digestion and extraction in aqua regia.
Robert Šajn, Mateja Gosar
doaj  

A Proof‐of‐Concept Study of Using a Less Permeable Slice Along the Shoreline to Increase Fresh Groundwater Storage of Oceanic Islands: Analytical and Experimental Validation [PDF]

, 2019
Chunhui Lu, Hongfan Cao, Jing Ma, Wenlong Shi, Saubhagya Singh Rathore, Jichun Wu, Jian Luo   +6 more
openalex   +1 more source

A Learning Analytics Approach to Identify Students at Risk of Dropout: A Case Study with a Technical Distance Education Course [PDF]

, 2020
Emanuel Marques Queiroga, João Ladislau Barbará Lopes, Kristofer S. Kappel, Marílton Sanchotene de Aguiar, Ricardo Araújo, Roberto Muñoz, Rodolfo Villarroel, Cristian Cechinel   +7 more
openalex   +1 more source