Results 141 to 150 of about 669,987 (295)

Integrating machine learning and explainable AI for employee attrition prediction in HR analytics. [PDF]

Sci Rep
Al-Ali M, Alwateer M, Alsaedi SA, Balaha HM, Badawy M, A Elhosseini M.   +5 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Lifestyle Medicine and Mitigating the Rising Cost of Healthcare. [PDF]

Am J Lifestyle Med
Bettini R, Sehgal V, Esquivel MK, Abraham AJ.   +3 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Enhancing healthcare outcome with scalable processing and predictive analytics via cloud healthcare API. [PDF]

Front Digit Health
Salehi SS, Saadatfar H, Oyelere SS, Hussain S, Hassannataj Joloudari J, Taheri Ledari M, Arslan E, Barzegar B.   +7 more
europepmc   +1 more source

Analytical and Clinical Validation of Direct Detection of Antimicrobial Resistance Markers by Plasma Microbial Cell-free DNA Sequencing [PDF]

Fred C. Christians, Jamilla Akhund‐Zade, Kristin H. Jarman, Shivkumar Venkatasubrahmanyam, Nicholas Noll, Timothy A. Blauwkamp, Sivan Bercovici, Aga Zielinska, Amy Carr, Arryn Craney, Matthew Pike, John J. Farrell, Sanjeet Dadwal, James B. Wood, Efrat Matkovich, Staci McAdams, Frederick S. Nolte   +16 more
openalex   +1 more source

SEMANTICS WITHIN THE FRAMEWORK OF THE ANALYTIC LANGUAGE IN TERMS OF PHRASEOLOGY

, 2023
DilraboYarmatova
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Data-Driven Futures: The Role of Analytics in the Olympic Rise of eSports

Revista Científica
Cesar Diaz, Hector Florez
doaj   +1 more source