Results 261 to 270 of about 3,624,229 (370)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Designing a Visual Analytics Tool to Support Data Analysis Tasks of Digital Mental Health Interventions: Case Study.

JMIR Hum Factors
Jung G, Lim H, Han K, Kim H, Lee U.
europepmc   +1 more source

VueGen: automating the generation of scientific reports. [PDF]

Bioinform Adv
Ayala-Ruano S, Webel H, Santos A.
europepmc   +1 more source

Analytic keys to the genera and species of North American mosses

, 1896
Charles Reid Barnes, Frederick De Forest Heald, Frederick De Forest Heald   +2 more
openalex   +2 more sources

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Advancing open-source visual analytics in digital pathology: A systematic review of tools, trends, and clinical applications. [PDF]

J Pathol Inform
Ahmad Z, Alzubaidi M, Al-Thelaya K, Calí C, Boughorbel S, Schneider J, Agus M.   +6 more
europepmc   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Personalised learning in higher education for health sciences: a scoping review. [PDF]

BMC Med Educ
Ali M, Wahab IA, Huri HZ, Yusoff MS.
europepmc   +1 more source

Twitter bot profiling [PDF]

, 2016
Living Analytics Research Centre
core   +1 more source

An Analytical Method for the Oscillations of Water in a Bay or Lake, using an Electric Network and an Electronic Analogue Computer

, 1955
Shizuwo ISHIGURO, Akimitsu FUJIKI
openalex   +2 more sources