Results 81 to 90 of about 2,985,531 (342)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Uncertainty and Analyticity [PDF]

, 2015
We describe a connection between minimal uncertainty states and holomorphy-type conditions on the images of the respective wavelet transform. The most familiar example is the Fock-Segal-Bargmann transform generated by the Gaussian, however, this also occurs under more general assumptions.
openaire   +3 more sources

The Systems Thinking Approach to Strategic Management

Systems
This paper presents a review of the field of systems thinking and strategic management The evolution of the areas of interest between systems thinking and strategic management follows similar patterns with more prescriptive developments occurring within ...
Martin Kunc
doaj   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Data Mining and Analytics in the Process Industry: The Role of Machine Learning

IEEE Access, 2017
Data mining and analytics have played an important role in knowledge discovery and decision making/supports in the process industry over the past several decades.
Zhiqiang Ge, Zhihuan Song, S. Ding, Biao Huang   +3 more
semanticscholar   +1 more source

Applying Web Analytics to Online Finding Aids: Page Views, Pathways, and Learning about Users

Journal of Western Archives, 2011
Online finding aids, Internet search tools, and increased access to the World Wide Web have greatly changed how patrons find archival collections. Through analyzing eighteen months of access data collected via Web analytics tools, this article examines ...
Mark R. O'English
doaj  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Prospects for Regional Development of Industrial Tourism in View of the Analysis of the Main Economic Indicators of Russian Tourism Industry

Economic and Social Changes: Facts, Trends, Forecast, 2017
The development of tourism industry at the regional level is relevant for all the subjects of the Russian Federation. The issue is especially acute in those of them that do not have rich cultural-historical heritage and unique natural-climatic conditions.
Yashalova Natal'ya N., Akimova Mariya A., Ruban Dmitrii A., Boiko Stanislav V., Usova Anna V., Mustafaeva Ellada R.   +5 more
doaj   +1 more source

Applying a 6 DoF Robotic Arm and Digital Twin to Automate Fan-Blade Reconditioning for Aerospace Maintenance, Repair, and Overhaul

Sensors, 2020
The UK is home to several major air commercial and transport hubs. As a result, there is a high demand for Maintenance, Repair, and Overhaul (MRO) services to ensure that fleets of aircraft are in airworthy conditions.
John Oyekan, Michael Farnsworth, Windo Hutabarat, David Miller, Ashutosh Tiwari   +4 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source