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The Doc1 subunit is a processivity factor for the anaphase-promoting complex
Nature Cell Biology, 2002Ubiquitin-mediated proteolysis of securin and mitotic cyclins is essential for exit from mitosis. The final step in ubiquitination of these and other proteins is catalysed by the anaphase-promoting complex (APC), a multi-subunit ubiquitin-protein ligase (E3).
Christopher W, Carroll, David O, Morgan
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Regulation of Anaphase Promoting Complex Coactivators
2010Ubiquitin-mediated proteolytic degradation is fundamental to eukaryotic cell cycle progression. From late mitosis through early G1, the Anaphase Promoting Complex (APC) is essential for cell-cycle relevant proteolytic degradation, and its activity is targeted to appropriate substrates by the evolutionarily conserved coactivators Cdc20 and Cdh1.
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