Results 91 to 100 of about 82,997 (306)

WSES classification and guidelines for liver trauma [PDF]

, 2016
The severity of liver injuries has been universally classified according to the American Association for the Surgery of Trauma (AAST) grading scale. In determining the optimal treatment strategy, however, the haemodynamic status and associated injuries ...
Abu-Zidan, Fikri M., Ansaloni, Luca, Biffl, Walter, Catena, Fausto, Ceresoli, Marco, Coccolini, Federico, Coimbra, Raul, Fraga, Gustavo, Ivatury, Rao, Kluger, Yoram, Montori, Giulia, Moore, Ernest E., Moore, Frederick A., Naidoo, Noel, Peitzman, Andrew, Rizoli, Sandro, Sartelli, Massimo, Weber, Dieter, Zanini, Nicola   +18 more
core   +2 more sources

Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity

Advanced Science, EarlyView.
Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu, Philippa J. Karoly, Sina Mansour L., Artemio Soto‐Breceda, Levin Kuhlmann, Mark J. Cook, David B. Grayden   +6 more
wiley   +1 more source

Futility of Up-Front Resection for Anatomically Resectable Pancreatic Cancer

JAMA Surgery
ImportanceThere are currently no clinically relevant criteria to predict a futile up-front pancreatectomy in patients with anatomically resectable pancreatic ductal adenocarcinoma.ObjectivesTo develop a futility risk model using a multi-institutional database and provide unified criteria associated with a futility likelihood below a safety threshold of
Crippa S., Malleo G., Mazzaferro V., Langella S., Ricci C., Casciani F., Belfiori G., Galati S., D'Ambra V., Lionetto G., Ferrero A., Casadei R., Ercolani G., Salvia R., Falconi M., Cucchetti A.   +15 more
openaire   +3 more sources

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Low Anterior Resection Syndrome. Anatomical Changes after Anterior Rectal Resection

Chirurgia
In this editorial, the authors bring to the attention of surgeons a personal point of view with the intention of offering a series of anatomical arguments to explain the high rate of functional complications following ultralow rectal resections, resections dominated by faecal incontinence of various intensities.
Virgiliu-Mihail, Prunoiu, Mircea-Niculae, Brătucu, Dragoş, Garofil, Victor, Strâmbu, Eugen, Brătucu, Laurenţiu, Simion, Eduard-Georgian, Chiru, Petru Adrian, Radu   +7 more
openaire   +2 more sources

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

CT and MRI imaging and interpretation of hepatic arterioportal shunts [PDF]

, 2019
Hepatic arterioportal shunts (HAPS) occur due to organic or functional fistulization of blood flow between arterial hepatic vasculature and venous portal systems.
Akisik, Fatih, Cui, Enming, Deng, Yu, Hu, Maoqing, Koniaris, Leonidas G., Milgrom, Daniel P., Patel, Aash, Wang, Qiushi   +7 more
core   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Unusual cause of acute lower extremity ischemia in a healthy 15-year-old female: A case report and review of popliteal artery aneurysm management in adolescents

Journal of Pediatric Surgery Case Reports, 2016
Limb ischemia in healthy teenagers is unusual. While traumatic or iatrogenic injury is the most common etiologies of limb ischemia in the pediatric population, anatomic variants such as true aneurysms should be considered [1].
David M. Notrica, Emilie Amaro, Maria E. Linnaus, Jozef Zoldos   +3 more
doaj   +1 more source