Results 31 to 40 of about 420,179 (261)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Anatomical characteristics and structural features of the optic nerve

Российский офтальмологический журнал
The review presents literature data about the anatomical structure, morphology and structural features of the optic nerve (ON). Four ON regions are detailed: intraocular, intraorbital, intracanalicular and intracranial.
T. N. Kiseleva, A. V. Baeva, E. K. Eliseeva, K. V. Lugovkina   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Comparison of some Anatomical properties of Suaeda Species (Amaranthaceae) in Anbar Governorate – Western Iraq

Tikrit Journal for Agricultural Sciences, 2023
     The current study aims to identify morphological and anatomical characteristics of the stems and leaves of some species of the genus Suaeda Belongs to (Amaranthaceae) grown in the western province of Anbar Governorate – Iraq.
Sameer Alrawi, Naglaa AL-abide , Harith Buniya   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Technological Characterization of Cupressus spp. Wood

Floresta e Ambiente
The objectives of the present study were to determine anatomical characteristics, mechanical properties and natural durability to two fungi types [Gloeophyllum trabeum (Persoon ex Fries) Murrill and Trametes versicolor (Linnaeus ex Fries)Pilat] for ...
Esmeralda Yoshico Arakaki Okino, Marcos Antonio Eduardo Santana, Marcus Vinicius da Silva Alves, Júlio Eustáquio de Melo, Vera Terezinha Rauber Coradin, Mário Rabelo de Souza, Divino Eterno Teixeira, Maria Eliete de Sousa   +7 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Anthropometric Characteristics, Age, Sex, Drop Height, and Visual Feedback as Predictors of Dynamic Knee Valgus During Single-Leg Drop Landing

Sports
The knee is a complex joint essential for locomotion, providing stability that is crucial for avoiding biomechanical deviations such as dynamic knee valgus (DKV), a contributing injury risk factor.
Nuno Casanova, David Correia, Priscila Marconcin, Fábio Flôres, Denise Soares, Rodrigo Ruivo   +5 more
doaj   +1 more source

Estrutura anatômica da madeira e qualidade do carvão de Mimosa tenuiflora (Willd.) Poir Anatonical structure and charcoal quality of Mimosa tenuiflora (Willd.) Poir. Wood

Revista Árvore, 2006
Este trabalho objetivou determinar algumas características anatômicas e dimensões de fibras, elementos dos vasos, células do parênquima e dos raios da madeira da Mimosa tenuiflora (Willd.) Poir.
Elisabeth de Oliveira, Benedito Rocha Vital, Alexandre Santos Pimenta, Ricardo Marius Della Lucia, Ana Márcia M. Ladeira, Angélica de Cássia Oliveira Carneiro   +5 more
doaj   +1 more source