Results 41 to 50 of about 140,188 (260)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

LEAF CHARACTERISTICS AND DNA ANALYSIS OF IN OF VITRO REGENERATED PLANTLETS DATE PALM (Phoenix dactylifera, L.) [PDF]

Journal of Plant Production, 2004
The in vitro regenerated plantlets of date palm (Phoenix daetylifera L.) cv. Sewi, Via somatic embryogenesis, were visually screened at an early stage of their development; one foliage leaf.
M. Abou-Bakr, A. Abd EI-Hamid,
doaj   +1 more source

MULTIVARIATE ANALYSIS OF THE STEM ANATOMICAL CHARACTERS OF TERMINALIA L. (COMBRETACEAE) IN EGYPT

Bulletin of the Iraq Natural History Museum, 2021
A comparative investigation of the anatomical characters through a microscopical examination of the prepared transverse sections of the stem wascarried out.
Nahed Waly, Heba Moustafa, Rim Hamdy, Ashraf Soliman   +3 more
doaj   +1 more source

Finite element analysis of a novel anatomical locking plate for scapular neck fracture

Journal of Orthopaedic Surgery and Research, 2023
Abstract Objectives Reconstruction plates (RPs) are commonly used in scapular neck fractures (SNFs): however, RPs have many defects. In this study, we evaluated a newly designed scapular neck anatomical locking compression plate (SNALCP). Methods An SNF finite element model (
Feifan Xiang, Yukun Xiao, Daiqing Wei, Xiaoqi Tan, Siyuan He, Liang Luo, Yunkang Yang   +6 more
openaire   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Anatomically realistic finite element simulations of Pelvic floor mechanics [PDF]

PAMM, 2007
AbstractAn anatomically realistic computational model of the pelvic floor and anal canal regions was used to examine the mechanics of normal defecatory function within the female pelvic floor. The subject specific model was constructed from MR images acquired from a healthy nulliparous 32 year old female.
Leo K. Cheng, Kimberley F. Noakes, Ian P. Bissett, Andrew J. Pullan   +3 more
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Minimum Data Set Of Anatomical Pathology Information System From The Perspective Of Experts

پیاورد سلامت, 2015
Background and Aim: Pathology Information Systems provide opportunities for pathologists and clinical laboratory professionals to influence clinical care and modern research programs.
Reza Safdari, Leila Shahmoradi, Maryam Ebrahimi   +2 more
doaj   +2 more sources