Results 101 to 110 of about 448,828 (287)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface. [PDF]

, 2018
Orofacial clefting represents the most common craniofacial birth defect. Cleft lip with or without cleft palate (CL/P) is genetically distinct from cleft palate only (CPO).
Berkes, Blaschke, Brendolan, Britanova, Buck, Bush, Capellini, Capellini, Capellini, Capellini, Choe, Clement-Jones, Cox, Cuadra-Blanco, Dixon, Dobreva, Elahi, Ferguson, Ferguson, Ferretti, Ficara, Ficara, Fuchs, Golonzhka, Gordon, Gordon, Gosain, Grebbin, Gritli-Linde, Gritli-Linde, Hebert, Hessle, Hill, Hilliard, Ho, Howe, Hurtado, Kim, Kim, Koss, Kousa, Lan, Lane, Leslie, Lewis, Li, Lidral, Longobardi, Losa, Manyama, Marazita, Martik, McCulley, Miletich, Minoux, Moens, Murphy, Okano, Pauws, Percival, Rhee, Richman, Roberts, Rosset, Sagerstrom, Satokata, Schnabel, Selleri, Selleri, Stankunas, Sun, Tam, Villaescusa, Welsh, Young, Yu, Yu, Zeytinoglu, Zhang   +78 more
core   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Kimmerle Anomaly – An Important Anatomical Variation

Online Journal of Health & Allied Sciences, 2018
The anatomy of the first vertebra, namely atlas, has significant clinical implications. One of the clinically significant anatomical variants is the presence of an arcuate foramen.
Serghei Covantev, Natalia Mazuruc, Olga Belic   +2 more
doaj  

Hand and foot pressures in the aye-aye (Daubentonia madagascariensis) reveal novel biomechanical trade-offs required for walking on gracile digits [PDF]

, 2010
Arboreal animals with prehensile hands must balance the complex demands of bone strength, grasping and manipulation. An informative example of this problem is that of the aye-aye (Daubentonia madagascariensis), a rare lemuriform primate that is unusual ...
Ancrenaz, Ashton, Cartmill, Cartmill, Cartmill, Curtis, D'Août, Demes, Dutto, Elftman, Erickson, Flannery, Gebo, Hamrick, Hunt, Inouye, Jouffroy, Jouffroy, Jouffroy, Kimura, Kimura, Krakauer, Lammers, Lammers, Lee, Lemelin, Lemelin, Lemelin, Lemelin, Lemelin, Lemelin, Lessertisseur, Milliken, Napier, Napier, Owen, Oxnard, Oxnard, Patel, Patel, Preuschoft, Preuschoft, Prost, Quinn, Raichlen, Raichlen, Reynolds, Richmond, Schaal, Scheumann, Schmitt, Schmitt, Simons, Soligo, Sterling, Strasser, Strasser, Susman, Swartz, Tuttle, Tuttle, Vereecke, Vereecke, Vilensky, Wunderlich, Wunderlich, Wunderlich   +66 more
core   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Anatomical Variations of Anterior Communicating Artery

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013
The Circle of Willis is a vascular network formed at the base of skull in the interpeduncular fossa. Its anterior part is formed by the anterior cerebral artery, from either side. Anterior communicating artery connects the right and left anterior cerebral arteries.
Poorwa Baburao Kardile, Jaideo Manohar Ughade, Sudhir Vishnupant Pandit, Manohar Namdeo Ughade   +3 more
openaire   +3 more sources

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

A study on the prevalence of the anconeus epitrochlearis muscle by magnetic resonance imaging

Revista Brasileira de Ortopedia
Objective To analyze magnetic resonance imaging (MRI) of the elbow area to quantify the presence of the anconeus epitrochlearis muscle. Methods A total of 232 exams were analyzed; 218 were included, of which 141 were of men and 77, women.
Sergio Ricardo Rios Nascimento, Cristiane Regina Ruiz   +1 more
doaj   +1 more source