Results 131 to 140 of about 2,454,008 (300)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

A rare case of an accessory sternohyoid muscle: case report

Folia Morphologica
BACKGROUND: Variability of the infrahyoid muscles is a well-known anatomical phenomenon; however, reports describing muscular variations and additional muscles remain limited, which may have clinical implications.
Agata Mazurek, Małgorzata Barczak, Ilie Lastovetskyi, Alicja Kluza, Grzegorz Fibiger, Kamil Możdżeń, Piotr Wites, Jerzy Walocha, Tomasz Kozioł   +8 more
doaj   +1 more source

Corona mortis: an anatomical variation with clinical relevance. Case report.

, 2010
The obturator artery is one of the parietal branches arising from the internal iliac artery, the anatomical variation from which this artery originates is called “The corona mortis”, generally from the external iliac artery or the inferior epigastric ...
Guillermo Adrián Rivera-Cardona, Néstor Alonso Perlaza-Ruiz   +1 more
core  

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

A combined anatomical variation of inferior epigastric vessels [PDF]

, 2012
During the routine anatomical dissection of a male cadaver, a variation was observed both in the inferior epigastric artery (IEA) and inferior epiastric vein (IEV).
Basar, R., Firat, A., Bilgin, S., Sargon, M.F., Gunenc Beser, C., Ercakmak, B.; Hacettepe University Faculty of Medicine Department of Anatomy   +5 more
core  

Singapore's anatomical future : Quo Vadis?

, 2012
The disciplines of anatomy and surgery are not dichotomous since one is dependent on the other. Traditionally, surgeons predominantly taught gross and clinical anatomy. In this review, we examine the context of how human anatomy is taught nowadays.
Hartman, Mikael, Bay, Boon-Huat, Abrahams, Peter H., Mikael Hartman, Hartman, M,, Eng-Tat Ang, Ang, E-T, Boon-Huat Bay, Sugand, Kapil, Bay, B-H, Abrahams, P, Ang, Eng-Tat, Seow, Choon-Sheong, Peter Abrahams, Sugand, K, Kapil Sugand, Choon-Sheong Seow, Seow, C-S   +17 more
core   +1 more source

Comparative Analysis of Choroid Plexus Volume Between MOG Antibody Associated Disease and Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Choroid plexus volume (CPV) has been proposed as a neuro‐immunological marker of multiple sclerosis (MS), but its relevance in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) remains uncertain. We analyzed CPV in 43 individuals with MOGAD, 48 with MS, and 44 healthy controls using a Bayesian Gaussian mixture modeling ...
Jae‐Won Hyun, Shaun G. Hong, Na Young Park, Su‐Hyun Kim, Ho Jin Kim   +4 more
wiley   +1 more source

Anatomical variation in twig wood across Australian angiosperms

, 2014
"May 2014""Thesis submitted for the degree of doctor of philosophy"Thesis by publication.Includes bibliographical references.1. Introducton -- 2. Dissecting stems: what can wood anatomy disclose about plant strategies? -- 3.
Ziemińska, Kasia
core  

Tinkering and the Origins of Heritable Anatomical Variation in Vertebrates

, 2018
Evolutionary change comes from natural and other forms of selection acting on existing anatomical and physiological variants. While much is known about selection, little is known about the details of how genetic mutation leads to the range of heritable ...
Jonathan B. L. Bard, Jonathan Bard
core   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source