Results 91 to 100 of about 671,057 (261)
Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb [PDF]
Mice are one of the most commonly used laboratory animals, with an extensive array of disease models in existence, including for many neuromuscular diseases.
Cappellari, O+5 more
core +9 more sources
Comparative Study of Brain Size Ontogeny: Marsupials and Placental Mammals
There exists a negative allometry between vertebrate brain size and body size. It has been well studied among placental mammals but less is known regarding marsupials.
Carmen De Miguel+3 more
doaj +1 more source
A metric to compare the anatomy variation between image time series [PDF]
Biological processes like growth, aging, and disease progression are generally studied with follow-up scans taken at different time points, i.e., with image time series (TS) based analysis. Comparison between TS representing a biological process of two individuals/populations is of interest.
arxiv
Ligand recognition by 14‐3‐3 proteins requires negative charges but not necessarily phosphorylation
Interactions of 14‐3‐3 proteins with their binding partners are attributed to phosphorylation of the binding partners. In this work, we show that at least one negative charge is required for the peptides to bind 14‐3‐3ε, although phosphorylation is not necessary, and that two negative charges are preferable for high affinity binding.
Seraphine Kamayirese+2 more
wiley +1 more source
Patched Diffusion Models for Unsupervised Anomaly Detection in Brain MRI [PDF]
The use of supervised deep learning techniques to detect pathologies in brain MRI scans can be challenging due to the diversity of brain anatomy and the need for annotated data sets. An alternative approach is to use unsupervised anomaly detection, which only requires sample-level labels of healthy brains to create a reference representation.
arxiv
Calcium‐sensing receptor‐ and ADAM10‐mediated klotho shedding is regulated by tetraspanin 5
The G protein‐coupled calcium‐sensing receptor (CaSR) and the disintegrin/metalloprotease ADAM10 in the renal distal convoluted tubule control systemic levels of Klotho, a cell and tissue homeostasis‐preserving factor. We show that CaSR‐induced cleavage of membrane‐bound αKlotho by ADAM10 requires tetraspanin 5 (Tspan5), a scaffolding and chaperone ...
Zhenan Liu+4 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Embryology and Evolution [PDF]
The proofs of evolution must be sought in the entire field of science. Direct proof is found in the study of Morphology, whose bases are comparative anatomy; embryology; in the study of paleontology, of geology, of geographical distribution, in the study
Amunson, Malo Marius
core +1 more source
Human and Comparative Anatomy at Oxford [PDF]
IN the article which appeared in your last number under the above heading, expressions occur which may, I think, lead to misconception as to the position of the department of Human Anatomy. It is of such importance in the interest of scientific medical education that the academical teaching of human anatomy should not consist merely in “technical ...
openaire +2 more sources
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard+7 more
wiley +1 more source