Results 71 to 80 of about 2,445,626 (292)

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

On the Comparative Anatomy of Transformations

The Annals of Mathematical Statistics, 1957
The attention of statisticians has usually been focussed on single transformations, rather than on families of transformations. With a growing appreciation of the advantages of examining the behavior of data or approximations over whole families of transformations (Moore and Tukey [2], Anscombe and Tukey [1]), there arises a need for rationally planned
openaire   +2 more sources

Neuro-hormonal Regulation Is a Better Indicator of Human Cognitive Abilities Than Brain Anatomy: The Need for a New Paradigm

Frontiers in Neuroanatomy, 2020
Human intelligence has been theorized since the ancient Greeks. Plato and Aristotle incorporated theories of human intelligence into their metaphysical and cosmological theories which informed the social and medical sciences for centuries.
Arthur Saniotis, Arthur Saniotis, James P. Grantham, James P. Grantham, Jaliya Kumaratilake, Maciej Henneberg, Maciej Henneberg   +6 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Human and Comparative Anatomy at Oxford [PDF]

Nature, 1893
IN the article which appeared in your last number under the above heading, expressions occur which may, I think, lead to misconception as to the position of the department of Human Anatomy. It is of such importance in the interest of scientific medical education that the academical teaching of human anatomy should not consist merely in “technical ...
openaire   +2 more sources

An Anatomical Study Using Computed Tomography, Magnetic Resonance Imaging, and Rhinoscopy of the Nasal Cavity of Domestic Cat (Felis silvestris catus L.) and Big Cats: Lion (Panthera leo leo L.), Leopard (Panthera pardus kotiya L.), and Cheetah (Acinonyx jubatus jubatus S.)

Animals
The objective of this work was to study the normal anatomy of the nasal cavity of the three species of big cats (leopard, lion, and cheetah) compared to the domestic cat through the use of computed tomography, magnetic resonance imaging, and rhinoscopy ...
Elena Díaz Martínez, Alberto Arencibia Espinosa, Marta Soler Laguía, David Kilroy, Francisco Martínez Gomariz, Diego Luis Casas García, Cayetano Sánchez Collado, Francisco Gil Cano, José Raduán Jaber, Gregorio Ramírez Zarzosa   +9 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Anthropological analysis of projectile trauma to the bony regions of the trunk

Anthropological Review, 2017
Ballistics literature often focuses on soft tissue injures and projectile trauma to the cranium. Minimal details on the bony characteristics of projectile trauma to the thorax/abdomen regions have been published.
Humphrey Caitlin, Henneberg Maciej
doaj   +1 more source

Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory

mBio, 2016
Antibiotic intervention is an effective treatment strategy for many bacterial infections and liberates bacterial antigens and stimulatory products that can induce an inflammatory response.
Joseph M. Benoun, Jasmine C. Labuda, Stephen J. McSorley   +2 more
doaj   +1 more source