Results 51 to 60 of about 1,237 (212)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Influencing Policy Production in the European Union: The European Commission Before the Court of Justice [PDF]
, 2009 The present paper addresses the role of the European Commission in shaping policy produced in the European Union. Most related studies have focussed on the Commission’s positions in legislative or executive politics.
Hofmann, Andreas
core
Locomotion in extinct giant kangaroos: were sthenurines hop-less monsters? [PDF]
, 2014 The extinct \u27sthenurine\u27 family of giant Kangaroos, up to three times larger than living Kangaroos, were able to walk on two feet, according to new research. Abstract Sthenurine kangaroos (Marsupialia, Diprotodontia, Macropodoidea) were an extinct
Christine M. Janis (644898) +6 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Understanding the Workflows in Non‐Guided and Static Computer‐Assisted Implant Surgery
Clinical and Experimental Dental ResearchContemporary implant dentistry aims to achieve long‐term biological, esthetic, and functional successful outcomes. Thus, instrumental to this aim is designing an integrated system in which the supported prosthesis & components, anatomical and ...
Adria Jorba‐Garcia +6 more
doaj +1 more source
Functional anatomy of the airway [PDF]
, 2012 Functional anatomy is very important to the doctors who are involved in the airway management. Attention to the details and subtleties of anatomy will often mean the difference between the success and failure of airway management.
Asha'ari, Zamzil Amin
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Collateral, relationship lending and financial distress : an empirical study on financial contracting [PDF]
, 2002 This paper analyses the role of collateral in loan contracting when companies are financed by multiple bank lenders and relationship lending can be present.
Elsas, Ralf, Krahnen, Jan Pieter
core
, 2022 Atrial fibrillation (AF) is the most common arrhythmia worldwide. Thromboembolism from the left atrial appendage (LAA) is the most feared complication in patients with AF.
Parodi G. +15 more
core +1 more source