Ancestral gene content estimates under gain-loss-duplication depend on the chosen observation threshold. [PDF]
Proc Natl Acad Sci U S ASzöllősi GJ, Williams TA.
europepmc +1 more source
Advanced Science, EarlyView.Computational simulations of tumor evolution are increasingly used to infer the rules underlying cancer growth, with the goal of one day recommending tailored treatments. Here we show that the properties of lung cancer sequencing data are best replicated by a model which assumes that cells compete both to proliferate and survive. ABSTRACT Computational
Helena Coggan +5 more
wiley +1 more source
The Worship of Job Ancestor in Hoian, Quangnam
, 2014 The worship of job ancestor is the belief about real people or legendary characters. They are respected, admired because they instituted career or brought career from other places to indoctrinate people. Each craftsmanship in Hoian always has the worship
Hường*, N. T. (Ngô)
core
CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction
Advanced Science, EarlyView.CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su +5 more
wiley +1 more source
UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression
Advanced Science, EarlyView.UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma +14 more
wiley +1 more source
Photosynthetic glyceraldehyde 3-phosphate dehydrogenase B is present in the last common ancestor of Viridiplantae predating the Streptophyta-Chlorophyta split. [PDF]
New PhytolMann AP +3 more
europepmc +1 more source
Physics‐Aware Machine‐Learning‐Driven Inverse Design of Broadband Ultra‐Open Acoustic Metamaterials
Advanced Science, EarlyView.A physics‐aware machine‐learning framework enables inverse design of ultra‐open acoustic silencers by decoupling spectral and radial design spaces. The approach rapidly identifies broadband, compact, and highly ventilated architectures, while revealing hidden linear design rules that link geometry, impedance matching, and acoustic performance.
Zhiwei Yang +5 more
wiley +1 more source
Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota
Advanced Science, EarlyView.Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal +25 more
wiley +1 more source
The Baladi cattle are a genetic sieve for indicine and African-taurine genomic loci with positive effects on adaptation to harsh Mediterranean environments. [PDF]
BMC GenomicsShabtay A +13 more
europepmc +1 more source