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Ancestral Sequence Reconstruction: Methods and Applications

2019
A major goal in the study of molecular evolution is to elucidate properties of ancestral proteins and to understand their adaption induced by changes in the environment. Due to the lack of macromolecular fossils, ancestral sequence reconstruction (ASR) is the only alternative to deduce sequences for evolutionary precursors of extant proteins.
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Yeast Ancestral Genome Reconstructions: The Possibilities of Computational Methods

2009
In 2006, a debate has risen on the question of the efficiency of bioinformatics methods to reconstruct mammalian ancestral genomes. Three years later, Gordon et al. (PLoS Genetics, 5(5), 2009) chose not to use automatic methods to build up the genome of a 100 million year old Saccharomyces cerevisiae ancestor.
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Methods for ancestral sequence reconstruction of large and complex protein families

2022
Ancestral sequence reconstruction is an established bioinformatic method for inferring the likely character states of the ancestors of a set of modern day biological sequences. Ancestral proteins are studied because they provide insight into how modern proteins have evolved and how they are able to perform their specific functions.
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Supertree Methods for Ancestral Divergence Dates and other Applications

2004
There are many ways to combine rooted phylogenetic trees with overlapping leaf sets into a single “supertree”. The most widely used method is MRP (matrix representation with parsimony analysis), but other direct methods have been developed recently. However, all these methods utilize typically only the discrete topology of the input trees and ignore ...
David Bryant, Charles Semple, Mike Steel
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A method for constructing maximum parsimony ancestral amino acid sequences on a given network

Journal of Theoretical Biology, 1973
Abstract A solution is presented for the problem of how to find ancestral codons which minimize the number of mutations over a given network of species for which character-states of aligned amino acid sequences among the contemporary species are known.
G W, Moore, J, Barnabas, M, Goodman
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A New Deneutrosophication Method Proposal for Use in Delphi Methods: Application in Ancestral Knowledge Analysis

International Journal of Neutrosophic Science
This study explores the rich cultural heritage of indigenous peoples and communities, whose traditions and adaptability have intrigued scholars interested in understanding their relevance in modern times. The Neutrosophic Delphi Method emerges as a vital tool in this research, offering a dynamic and versatile approach to address the inherent complexity
Edwin Edwin   +2 more
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Uncertainty in the reconstruction of ancestral character states and limitations on the use of phylogenetic comparative methods

Animal Behaviour, 1999
Phylogenetic approaches to the study of comparative data have a long history in the field of animal behaviour (e.g. Lorenz 1941; Greene & Burghardt 1978; Gittleman 1981). However, since the publication in 1991 of Brooks & McLennan’s Phylogeny, Ecology and Behavior and Harvey & Pagel’s The Comparative Method in Evolutionary Biology, there has been a ...
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Paleontology and the Comparative Method: Ancestral Node Reconstructions versus Observed Node Values

The American Naturalist, 2001
Comparative methods are used to reconstruct ancestral node values for continuously varying traits. The confidence intervals (CIs) around such estimates may be wider than the range of tip data from which they are calculated. Without historical data with which to compare estimates, it is not clear whether such broad CIs reflect evolutionary lability or ...
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METHODS AND SYSTEMS FOR DETERMINING ANCESTRAL RELATEDNESS

2022
SAMS AARON J   +5 more
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