Results 181 to 190 of about 92,975 (280)

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

New insights into tragulid phylogeny of Europe: Dorcatherium naui from the latest Middle Miocene of Austria [PDF]

, 2013
Aiglstorfer, Manuela, Böhme, Madelaine, Rößner, Gertrud E., Wörheide, Gert   +3 more
core   +1 more source

Low‐Cost and Detunable Wireless Resonator Glasses for Enhanced Eye MRI With Concurrent High‐Quality Whole‐Brain MRI

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT PurposeTo develop a wearable wireless resonator glasses design that enhances eye MRI signal‐to‐noise ratio (SNR) without compromising whole‐brain image quality at 7 T. MethodsThe device integrates two detunable LC loop resonators into a lightweight, 3D‐printed frame positioned near the eyes.
Ming Lu, Xiaoyue Yang, Jason E. Moore, Pingping Li, Adam W. Anderson, John C. Gore, Seth A. Smith, Xinqiang Yan   +7 more
wiley   +1 more source

Single‐Breathhold 3D MR Elastography in the Liver, With Simultaneous R2* and PDFF Mapping

Magnetic Resonance in Medicine, EarlyView.
Purpose To develop a sequence for the rapid acquisition of MR elastography (MRE) parameters in 3D, with simultaneous measurement of proton‐density fat fraction (PDFF) and R2* for multiparametric assessment of liver disease. Methods The proposed sequence uses an interleaved motion‐encoding scheme to acquire 3D volumes of all motion encodings and wave ...
Donovan P Tripp, Anne‐Sophie van Schelt, Omar Darwish, Karl P Kunze, Shamsa Al Harthy, Nader S Metwalli, Ahmed M Gharib, Claudia Prieto, René M Botnar, Ralph Sinkus, Radhouene Neji   +10 more
wiley   +1 more source

Polarising SNPs Without Outgroup. [PDF]

Mol Ecol Resour
Liang J, Dutheil JY.
europepmc   +1 more source

Biogeography and diversification patterns in the Irano‐Turanian biodiversity hotspots inferred from a molecular phylogeny of the subendemic Iris subgenus Scorpiris (Iridaceae)

Nordic Journal of Botany, EarlyView.
The Irano‐Turanian Floristic Region harbors a rich flora, but our understanding of the development of this diversity is limited by a lack of data on phylogenetic relationships and biogeographic patterns of endemic and more widespread plants. Hypotheses of in situ diversification versus allopatric diversification were tested using Iris subgen. Scorpiris,
Mona Salimbahrami, Hojjatollah Saeidi, Ali Bagheri, Carol A. Wilson, Gerald M. Schneeweiss   +4 more
wiley   +1 more source

Phylogenetic insights into the diversification of cutting strategies in leaf-cutting ants. [PDF]

Front Insect Sci
Sánchez-Restrepo AF, Confalonieri VA, Calcaterra LA.   +2 more
europepmc   +1 more source

The Association of Pregnancy and Scurvy in Indigenous Women and Their Children From the Late Holocene in California (USA)

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Limited evidence of nutritional deficiencies has been identified in bioarchaeological studies of Native California populations, although isotopic and ethnohistoric research provides evidence of regional, seasonal, and cultural variability in food shortages.
Alyson Caine, Christopher Canzonieri, Eric J. Bartelink, Andrew Galvan   +3 more
wiley   +1 more source

Evolution of Animal Parasitism in Nematodes of the Suborder Spirurina. [PDF]

Ecol Evol
Nagae S, Hasegawa K.
europepmc   +1 more source

The relative roles of in situ diversification and lineage dispersal underlying diversity patterns at the assemblage level

Oikos, EarlyView.
Speciation, extinction, and dispersal are the historical processes influencing the spatial distribution of lineages and strongly influence diversity patterns. Here, we apply a recently developed methodological approach to quantify the relative legacies in situ diversification history (i.e.
Arthur Vinicius Rodrigues, Gabriel Nakamura, Leandro Duarte   +2 more
wiley   +1 more source