Results 51 to 60 of about 143,233 (268)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Anchoring the genome [PDF]

Genome Biology, 2008
Although the principles governing chromosomal architecture are largely unresolved, there is evidence that higher-order chromatin folding is mediated by the anchoring of specific DNA sequences to the nuclear matrix. These genome anchors are also crucial regulators of gene expression and DNA replication, and play a role in pathogenesis.
Ottaviani, D, Lever, E, Takousis, P, Sheer, D   +3 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Migración, territorio y transnacionalismo: Peruanos en una ciudad global del Sur

Cahiers des Amériques Latines, 2019
Since the nineties, a new migratory flow of Peruvians to Argentina have been activated as part of the South-South regional proximity dynamics. This article approaches, from a transnational perspective, the Peru-Argentina migratory field, oriented to ...
Susana María Sassone, Marina Laura Lapenda   +1 more
doaj   +1 more source

Implementing Anchoring [PDF]

, 2006
In an earlier paper we introduced Anchoring, a new approach for handling indeterminate location in a spatial information system. Here we develop it further, showing how Anchoring can be made to work in real systems. In particular, we specify a new kind of locational component for a spatial data model.
James Hood, Antony Galton
openaire   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Twenty years development and prospect of rapid coal mine roadway excavation in China

Meitan xuebao
Coal mine excavation faces some new opportunities and challenges under the rapid development of intelligent coal mines. In order to promote intelligent tunneling rapidly and healthily, a comprehensive review about the 20 years development of rapid coal ...
Hong WANG, Mingjun CHEN, Xiaofeng ZHANG
doaj   +1 more source

Anchoring without scale distortion [PDF]

Judgment and Decision Making, 2021
The scale distortion theory of anchoring argues that people are influenced by a previously considered numeric value, an anchor, because the anchor distorts the scale on which a subsequent judgment is made. The distortion of the scale due to the anchor is
Štěpán Bahník
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source