Results 71 to 80 of about 25,294,375 (318)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Anchoring Science and Technology in Greco-Roman Antiquity [PDF]
This collection of essays explores processes of innovation in Greco-Roman technology and science. It uses the concept of ‘anchoring’ to investigate the microhistories of technological and scientific practices and ideas.
core +2 more sources
Do different anchors generate the equivalent anchoring effect? Comparison of the effect size among different anchors. [PDF]
, 2018 Anchoring effect, the effect of precedent stimuli on subsequentnumerical estimation, is one of the most studied topics injudgment and decision making. Many researchers haveexamined its psychological processes from many perspectives.However, few studies have directly compared strength ofanchoring effects generated by different anchor types.
Onuki, Yutaro +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
How Does Prompt Anchoring Affect Large Language Model Outputs?
PublicationsThis study examines how different prompt anchoring strategies influence the conceptual representation of LLM-generated keywords and compares those effects with the effects of model selection.
Eungi Kim
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Field Experiments on Anchoring of Economic Valuations [PDF]
A pillar of behavioral research is the view that preferences are constructed during the value elicitation process, but it is unclear whether, and to what extent, such biases influence real market equilibria. This paper examines the “anchoring” phenomenon
Craig E. Landry +2 more
core
An Investigation into Bolt Anchoring Performance during Tunnel Construction in Bedded Rock Mass
Applied Sciences, 2020 The anchor bolt is a key point of tunnel design in bedded rock mass. The previous theory of anchorage support falls does not fulfil engineering requirements, and the stability of bedded rock must be addressed by empirical methods. To investigate the bolt
Zhiqiang Zhang +4 more
doaj +1 more source