Results 151 to 160 of about 1,934 (212)

FROM CRITICAL THINKING TO d‐CRITICAL THINKING: RECONSTRUCTING DEWEY'S SENSE OF CRITICAL IN HOW WE THINK

Educational Theory, EarlyView.
Abstract In this article, I reexamine John Dewey's original sense of critical in How We Think (first published in 1910), arguing that contemporary discourse about critical thinking reveals a process of lexicalization through which the term critical has lost its meaning. This article finds that Dewey's original sense of critical (which I term d‐Critical)
Matthew Landers
wiley   +1 more source

Sick leave in the United Kingdom Post Office, 1850–1908

The Economic History Review, EarlyView.
Abstract This paper uses a large individual‐record‐level dataset on sick leave to examine adult morbidity in the United Kingdom between 1850 and 1908. From 1859 onwards postal workers were eligible to receive a pension or gratuity when they retired or were forced to stop working due to ill health.
Harry Smith, David R. Green, Laura Newman, Joe Chick, Kathleen McIlvenna, Holly Marley, Natasha Preger, Douglas Brown, Nicola Shelton   +8 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

A 40‐year‐old woman with a spinal mass

Brain Pathology, EarlyView.
Melissa Mejia‐Bautista, Margarita Loxas, Pouya Jamshidi, Drew Duckett, Jean‐Paul Wolinsky, Jared T. Ahrendsen   +5 more
wiley   +1 more source

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

The FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose   +3 more
wiley   +1 more source

Water, water, every where—the advent of hydrated pili structure

The FEBS Journal, EarlyView.
Protein structure is defined by its surrounding water. Naturally, this is also true for the gigantic protein filaments that pathogenic bacteria use to attach to and colonize their host cells. Structures of these filaments for which water can be identified with high confidence have stayed elusive for the longest time.
Hiroya Oki, Hideki Shigematsu, Kazuki Kawahara, Christoph Gerle   +3 more
wiley   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

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Infectious diseases in ancient Egypt

Infectious Disease Clinics of North America, 2004
Techniques for studying infectious disease in the ancient world are discussed. A brief survey of infectious diseases, such as schistosomiasis and malaria, in ancient Egypt is presented, and the physical traces of these diseases are examined. A discussion of the ancient Egyptian physician's response to infectious disease is included.
exaly   +3 more sources

The eye and its diseases in Ancient Egypt

Acta Ophthalmologica, 1997
Based on a study of mummies, skeletons, burial rites, medical instruments, medicaments, literature and objets d'art from Ancient Egypt before the Hellenistic Period, the understanding of the eye, its diseases and their treatment at that time is described. Magic spells, religious rites and medical treatments, especially with eye ointments, were probably
exaly   +3 more sources