Results 101 to 110 of about 3,058,157 (220)

Discovery of the Principal Cystic Fibrosis Mutation (F508del) in Ancient DNA from Iron Age Europeans [PDF]

, 2007
The most common, life-threatening autosomal recessive disease of Europeans and Euro-Americans, cystic fibrosis (CF), occurs predominately in patients with the F508del mutation.1 Although F508del is currently detectable as a single allele in 1/30-1/40 ...
Cedric Le Marechal, Claude Ferec, Malika Siker, Maria Teschler-Nicola, Philip Farrell   +4 more
core   +1 more source

Paleogenomics: reconstruction of plant evolutionary trajectories from modern and ancient DNA

Genome Biology, 2019
How contemporary plant genomes originated and evolved is a fascinating question. One approach uses reference genomes from extant species to reconstruct the sequence and structure of their common ancestors over deep timescales.
C. Pont, S. Wagner, A. Kremer, L. Orlando, C. Plomion, J. Salse   +5 more
semanticscholar   +1 more source

An efficient pipeline for ancient DNA mapping and recovery of endogenous ancient DNA from whole‐genome sequencing data

Ecology and Evolution, 2020
Ancient DNA research has developed rapidly over the past few decades due to improvements in PCR and next‐generation sequencing (NGS) technologies, but challenges still exist.
W. Xu, Yu Lin, Keliang Zhao, Haimeng Li, Yinping Tian, J. Ngatia, Yue Ma, Sunil Kumar Sahu, Huabing Guo, Xiaosen Guo, Y. Xu, Huan Liu, K. Kristiansen, Tianming Lan, Xinying Zhou   +14 more
semanticscholar   +1 more source

Massive migration from the steppe is a source for Indo-European languages in Europe

, 2015
We generated genome-wide data from 69 Europeans who lived between 8,000-3,000 years ago by enriching ancient DNA libraries for a target set of almost four hundred thousand polymorphisms. Enrichment of these positions decreases the sequencing required for
A Keller, A Seguin-Orlando, Alan Cooper, Aleksandr Khokhlov, Alissa Mittnik, Anna Szécsényi-Nagy, AW Briggs, AW Briggs, Bastien Llamas, C Der Sarkissian, C Gamba, C Renfrew, Christina Roth, Christos Economou, D Reich, David Anthony, David Reich, DH Alexander, DH Alexander, DM Behar, Dorcas Brown, DW Anthony, Eadaoin Harney, Eszter Bánffy, Fredrik Hallgren, G Brandt, G Hellenthal, Guido Brandt, H Li, Harald Meller, I Lazaridis, I Olalde, Iosif Lazaridis, J Czebreszuk, Joachim Wahl, Johannes Krause, JP Mallory, Kristin Stewardson, Kurt Werner Alt, M Kircher, M Lipson, M Meyer, M Raghavan, Manuel A. Rojo Guerra, Matthias Meyer, Michael Francken, Michael Kunst, N Patterson, N Rohland, N Rohland, N Rohland, Nadin Rohland, Nick Patterson, Nicole Nicklisch, NM Myres, Oleg Mochalov, P Bellwood, P Ralph, P Skoglund, P Skoglund, P Skoglund, PA Underhill, Pavel Kuznetsov, Q Fu, Q Fu, Q Fu, Qiaomei Fu, Rafael Garrido Pena, RE Green, Roberto Risch, S Purcell, S Sawyer, Sandra L. Pichler, Susanne Friederich, Susanne Nordenfelt, Swapan Mallick, T Lassmann, TV Gamkrelidze, Valery Khartanovich, Vayacheslav Moiseyev, W Haak, Wolfgang Haak   +81 more
core   +2 more sources

Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus

Nature, 2017
Recent genomic data have revealed multiple interactions between Neanderthals and modern humans, but there is currently little genetic evidence regarding Neanderthal behaviour, diet, or disease.
L. Weyrich, S. Duchêne, J. Soubrier, Luis A. Arriola, B. Llamas, J. Breen, A. Morris, K. Alt, D. Caramelli, Veit Dresely, M. Farrell, A. Farrer, M. Francken, N. Gully, W. Haak, K. Hardy, K. Harvati, Petra Held, E. Holmes, J. Kaidonis, C. Lalueza-Fox, M. Rasilla, A. Rosas, P. Semal, Arkadiusz Sołtysiak, G. Townsend, D. Usai, J. Wahl, D. Huson, K. Dobney, A. Cooper   +30 more
semanticscholar   +1 more source

Ancient DNA – history of life [PDF]

, 2009
Drevna DNA predmet je mnogih istraživanja današnjice. Intrigira brojne znanstvenike koji proučavaju genetički materijal povijesnih ostataka kako bi interpretirali njihovo biološko i socijalno značenje.
Sviben, Sanja
core  

Human tuberculosis - an ancient disease, as elucidated by ancient microbial biomolecules [PDF]

, 2009
Tuberculosis is a major cause of death but infected people with effective immunity may remain healthy for years, suggesting long-term coexistence of host and pathogen.
Donoghue, HD
core   +1 more source

Index hopping on the Illumina HiseqX platform and its consequences for ancient DNA studies

Molecular Ecology Resources, 2019
The high‐throughput capacities of the Illumina sequencing platforms and the possibility to label samples individually have encouraged wide use of sample multiplexing. However, this practice results in read misassignment (usually
Tom van der Valk, F. Vezzi, M. Ormestad, L. Dalén, K. Guschanski   +4 more
semanticscholar   +1 more source

Optimized in-solution enrichment of over a million ancient human SNPs

Genome Biology
Background In-solution hybridization enrichment of genetic markers is a method of choice in paleogenomic studies, where the DNA of interest is generally heavily fragmented and contaminated with environmental DNA, and where the retrieval of genetic data ...
Roberta Davidson, Xavier Roca-Rada, Shyamsundar Ravishankar, Leonard Taufik, Christian Haarkötter, Evelyn Collen, Matthew P. Williams, Peter Webb, M. Irfan Mahmud, Erlin Novita Idje Djami, Gludhug A. Purnomo, Cristina Santos, Assumpció Malgosa, Linda R. Manzanilla, Ana Maria Silva, Sofia Tereso, Vítor Matos, Pedro C. Carvalho, Teresa Fernandes, Anne-France Maurer, João C. Teixeira, Raymond Tobler, Lars Fehren-Schmitz, Bastien Llamas   +23 more
doaj   +1 more source

Ancient DNA reveals genetic connections between early Di-Qiang and Han Chinese

BMC Evolutionary Biology, 2017
Background Ancient Di-Qiang people once resided in the Ganqing region of China, adjacent to the Central Plain area from where Han Chinese originated. While gene flow between the Di-Qiang and Han Chinese has been proposed, there is no evidence to support ...
Jiawei Li, Wen Zeng, Ye Zhang, Albert Min-Shan Ko, Chunxiang Li, Hong Zhu, Qiaomei Fu, Hui Zhou   +7 more
doaj   +1 more source