Results 211 to 220 of about 3,058,276 (339)

Ancient DNA reconstruction of late holocene ecosystems within the Carpathian basin from paleo-meanders and archaeological deposits. [PDF]

Sci Rep
Zampirolo G, H Ruter A, Živaljević I, Penezić K, Thomsen PF, Orton D, Grubin MK, Antić N, Pedersen MW.   +8 more
europepmc   +1 more source

Intrinsic specificity of a ‘core’ TIP60 acetyltransferase complex in Drosophila

The FEBS Journal, EarlyView.
The intrinsic substrate selectivity of the Drosophila TIP60‐core acetyltransferase was determined using synthetic nucleosome arrays. Targeted mass spectrometry revealed site‐specific acetylation of histones H2A, H2A.V, and H4, uncovering distinct acetylation rates and patterns across individual lysines.
Silke Krause, Marco Borsò, Marisa Müller, Axel Imhof, Zivkos Apostolou, Peter B. Becker   +5 more
wiley   +1 more source

Early colonization before inundation consistent with northern glacial refugia in Southern Doggerland revealed by sedimentary ancient DNA. [PDF]

Proc Natl Acad Sci U S A
Allaby RG, Ware R, Cribdon R, Hansford TA, Kinnaird T, Hamilton D, Kistler L, Murgatroyd P, Bates R, Fitch S, Gaffney V.   +10 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Reconstruction of the human peopling of Europe: a genetic insight

Annals of Human Biology, 2021
David Caramelli, Cosimo Posth, Olga Rickards   +2 more
doaj   +1 more source

Tracing 2500 years of human betaherpesvirus 6A and 6B diversity through ancient DNA. [PDF]

Sci Adv
Guellil M, van Dorp L, Saag L, Beneker O, Bonucci B, Sasso S, Saupe T, Solnik A, Kabral H, Allmäe R, Bates J, Dittmar JM, Ge XJ, Inskip S, Jonuks T, Karmanov VN, Khartanovich VI, Larmuseau MHD, Aneli S, Cessford C, Kriiska A, Mägi M, Malve M, De Winter N, Metspalu M, Pagani L, Robb JE, Kivisild T, Houldcroft CJ, Scheib CL, Tambets K.   +30 more
europepmc   +1 more source

Uncovering a previously unknown function of polyphosphate in polyadenylated RNA‐induced amyloidogenesis of Hfq

The FEBS Journal, EarlyView.
Polyphosphate interaction with Hfq and RNA drives phase separation and amyloid self‐assembly, uncovering a previously unrecognized role for polyP in bacterial stress responses. Our findings reveal new insights into the molecular mechanisms of RNA‐mediated phase separation, highlighting the role of polyP as a key modulator of this process. Polyphosphate
Kevin Mosca, Florian Turbant, Sambhasan Banerjee, Frank Wien, Richard R. Sinden, Véronique Arluison   +5 more
wiley   +1 more source

Ancient DNA from Shimao city records kinship practices in Neolithic China. [PDF]

Nature
Chen Z, Gardner JD, Sun Z, Bennett EA, Han Q, Pei X, Shao J, Shi H, Wang W, Xue J, Bai F, Dai X, He N, Guo X, Di N, Mao X, Liu T, Cao P, Liu F, Dai Q, Feng X, Ping W, Wu X, Zhang L, Chen L, Fu Q.   +25 more
europepmc   +1 more source

Isolating the human cochlea to generate bone powder for ancient DNA analysis

Nature Protocols, 2019
R. Pinhasi, D. Fernandes, K. Sirak, O. Cheronet   +3 more
semanticscholar   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source