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Results 41 to 50 of about 654 (165)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source

Research on joint clearing of energy and ancillary service in the day-ahead market considering the weights of ancillary services

Frontiers in Energy Research
IntroductionWith the large-scale grid integration of renewable sources and the increasing number of new types of loads, the demand for ancillary services in the power system has been growing rapidly.
Dong Mo +5 more
doaj +1 more source

A Coordinated Bidding Model for Wind Plant and Compressed Air Energy Storage Systems in the Energy and Ancillary Service Markets Using a Distributionally Robust Optimization Approach

IEEE Access, 2021
Clean energy resources, like wind, have a stochastic nature, which involves uncertainties in the power system. Introducing energy storage systems (ESS) to the network can compensate for the uncertainty in wind plant output and allow the plant to ...
Mohsen Aldaadi +3 more
doaj +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source

Synergies of Electric Vehicle Multi-Use: Analyzing the Implementation Effort for Use Case Combinations in Smart E-Mobility

Energies, 2023
Electromobility is generally seen as an efficient means of decarbonizing the transport sector. Ensuring both a broad propagation of electric vehicles and a stable energy system requires intelligent charging strategies in the form of use cases.
Patrick Vollmuth, Maximilian Hampel
doaj +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro +14 more
wiley +1 more source

Evaluation of a Novel Electric Health Record Sidecar Application to Display Rheumatoid Arthritis Clinical Outcomes During Clinic Visits: Results of a Stepped‐Wedge Cluster Randomized Pragmatic Trial

Arthritis Care &Research, EarlyView.
Objective We developed a novel electronic health record sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk +16 more
wiley +1 more source

A Simulation of Market-based Non-frequency Ancillary Service Procurement Based on Demand Flexibility

Journal of Modern Power Systems and Clean Energy, 2023
This paper proposes a novel approach for the provision of non-frequency ancillary service (AS) by consumers connected to low-voltage distribution networks. The proposed approach considers an asymmetric pool-based local market for AS negotiation, allowing
Ricardo Faia +6 more
doaj +1 more source

Cumulative Social Disadvantage and Disease Activity in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study

Arthritis Care &Research, EarlyView.
Objective Social determinants of health (SDOH) contribute to juvenile idiopathic arthritis (JIA) disparities, but most studies have assessed SDOH independently rather than cumulatively across individual, family, and neighborhood levels. Using a socioecological framework, we investigated the relationship among cumulative social disadvantage ...
William Daniel Soulsby +448 more
wiley +1 more source

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