Results 51 to 60 of about 63,661 (256)

Smart Buildings: Systems and Drivers

Buildings, 2020
Since the 1980s, smart buildings have aroused the interest of researchers. However, there is still no consensus on what the intelligence of a building is, and what enhances that intelligence.
Mariangela Monteiro Froufe, Christine Kowal Chinelli, André Luis Azevedo Guedes, Assed Naked Haddad, Ahmed W. A. Hammad, Carlos Alberto Pereira Soares   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Prediction of the Properties of Vibro-Centrifuged Variatropic Concrete in Aggressive Environments Using Machine Learning Methods

Buildings
In recent years, one of the most promising areas in modern concrete science and the technology of reinforced concrete structures is the technology of vibro-centrifugation of concrete, which makes it possible to obtain reinforced concrete elements with a ...
Alexey N. Beskopylny, Sergey A. Stel’makh, Evgenii M. Shcherban’, Irina Razveeva, Alexey Kozhakin, Anton Pembek, Tatiana N. Kondratieva, Diana Elshaeva, Andrei Chernil’nik, Nikita Beskopylny   +9 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Composition and Properties of Lightweight Concrete of Variotropic Structure Based on Combined Aggregate and Microsilica

Buildings
The use of artificial porous aggregates for the production of lightweight cement concrete is widespread and used everywhere. In most cases, lightweight artificial aggregates are used to produce concrete of the standard structure using vibration ...
Evgenii M. Shcherban’, Sergey A. Stel’makh, Levon R. Mailyan, Alexey N. Beskopylny, Alexander L. Mailyan, Natalya Shcherban’, Andrei Chernil’nik, Diana Elshaeva   +7 more
doaj   +1 more source

Effectiveness of using WiFi technologies to detect and predict building occupancy

Sustainable Buildings, 2017
This paper presents findings of a case-study demonstrating the effectiveness of using WiFi networks to detect occupancy as opposed to CO2 sensors, commonly used for demand-controlled heating, ventilation and air conditioning (HVAC) systems.
Ouf Mohamed M., Issa Mohamed H., Azzouz Afaf, Sadick Abdul-Manan   +3 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source