Results 71 to 80 of about 63,661 (256)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

A parsimonious software sensor for estimating the individual dynamic pattern of methane emissions from cattle

Animal, 2019
Large efforts have been deployed in developing methods to estimate methane emissions from cattle. For large scale applications, accurate and inexpensive methane predictors are required.
R. Muñoz-Tamayo, J.F. Ramírez Agudelo, R.J. Dewhurst, G. Miller, T. Vernon, H. Kettle   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Compressive Strength of Geopolymer Concrete Prediction Using Machine Learning Methods

Algorithms
The implementation of machine learning methods as one of the artificial intelligence technologies has allowed bringing the construction process to a new qualitative level.
Sergey A. Stel’makh, Alexey N. Beskopylny, Evgenii M. Shcherban’, Irina Razveeva, Samson Oganesyan, Diana M. Shakhalieva, Andrei Chernil’nik, Gleb Onore   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Computer Vision Method for Automatic Detection of Microstructure Defects of Concrete

Sensors
The search for structural and microstructural defects using simple human vision is associated with significant errors in determining voids, large pores, and violations of the integrity and compactness of particle packing in the micro- and macrostructure ...
Alexey N. Beskopylny, Sergey A. Stel’makh, Evgenii M. Shcherban’, Irina Razveeva, Alexey Kozhakin, Besarion Meskhi, Andrei Chernil’nik, Diana Elshaeva, Oksana Ananova, Mikhail Girya, Timur Nurkhabinov, Nikita Beskopylny   +11 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Crushed Stone Grain Shapes Classification Using Convolutional Neural Networks

Buildings
Currently, intelligent technologies are becoming both a topical subject for theoretical discussions and a proper tool for transforming traditional industries, including the construction industry.
Alexey N. Beskopylny, Evgenii M. Shcherban’, Sergey A. Stel’makh, Irina Razveeva, Alexander L. Mailyan, Diana Elshaeva, Andrei Chernil’nik, Nadezhda I. Nikora, Gleb Onore   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source