Results 81 to 90 of about 63,661 (256)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Impact of Manufacturing Technology on the Tube-Steel Concrete Columns Bearing Capacity Under Axial Load

Buildings
Current construction puts forward new requirements for the construction of important buildings and structures every year. In this regard, new approaches to the design of buildings and structures using modern types of structural elements should take ...
Evgenii M. Shcherban’, Alexey N. Beskopylny, Sergei A. Stel’makh, Levon R. Mailyan, Ivan A. Panfilov, Alexander L. Mailyan, Natalya Shcherban’, Ivan Vialikov, Diana Elshaeva, Andrei Chernilnik   +9 more
doaj   +1 more source

Building Physics and Building Energy Systems [PDF]

, 2021
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Structure and Properties Improvement by Recipe Factors of Geopolymer Basalt Fiber Reinforced Concrete for Building Enclosing Structures

Buildings
The application of geopolymer concrete in buildings and structures is becoming widespread because of its low cost and high strength characteristics. At the same time, the capabilities of geopolymer concrete are not fully used, especially to strengthen ...
Kirill P. Zubarev, Evgenii M. Shcherban’, Sergey A. Stel’makh, Alexey N. Beskopylny, Diana Elshaeva, Andrei Chernil’nik, Nadezhda I. Zakieva, Elena V. Pimenova, Alexandr A. Shilov   +8 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Finite Element Modeling and Experimental Study of Foam Concrete and Polystyrene Concrete

Buildings
Predicting the physical and mechanical properties of polystyrene concrete is an important tool for determining its performance under various conditions.
Alexey N. Beskopylny, Sergey A. Stel’makh, Evgenii M. Shcherban’, Diana M. Shakhalieva, Andrei Chernil’nik, Ivan Panfilov, Nikita Beskopylny, Yasin Onuralp Özkılıç   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Predicting the Strength of Heavy Concrete Exposed to Aggressive Environmental Influences by Machine Learning Methods

Buildings
Currently, intelligent algorithms are becoming a reliable alternative source of data analysis in many areas of human activity. In materials science, the integration of machine learning methods is effectively applied to predictive modeling of building ...
Kirill P. Zubarev, Irina Razveeva, Alexey N. Beskopylny, Sergey A. Stel’makh, Evgenii M. Shcherban’, Levon R. Mailyan, Diana M. Shakhalieva, Andrei Chernil’nik, Nadezhda I. Nikora   +8 more
doaj   +1 more source