Results 151 to 160 of about 10,013,914 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Publisher Correction: Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants. [PDF]

Genome Biol
Kim W, Hu X, Kim K, Chun S, Orchard P, Qiao D, Ruczinski I, Saferali A, Aguet F, Antonacci-Fulton L, Balte PP, Bartz TM, Anamika WJ, Zhou X, Duan J, Brody JA, Cade BE, Daviglus ML, Doddapaneni H, Dugan-Perez S, Dutcher SK, Frazar CD, Gabriel SB, Gharib SA, Gupta N, Hobbs BD, Kasela S, Loehr LR, Metcalf GA, Muzny DM, Oelsner EC, Rasmussen-Torvik LJ, Sitlani CM, Smith J, Sofer T, Xu H, Yu B, Zhang D, Ziniti J, Barr RG, Carson AP, Fornage M, Hou L, Kalhan R, Kaplan R, Lappalainen T, London SJ, Morrison AC, O'Connor GT, Psaty BM, Raffield LM, Redline S, Rich SS, Rotter JI, Silverman EK, Manichaikul A, Cho MH.   +56 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey.

Journal of the American Medical Association (JAMA), 1998
D. Eisenberg, Roger B. Davis, S. Ettner, Sarit Appel, Sonja Wilkey, M. Rompay, Ronald C. Kessler   +6 more
semanticscholar   +1 more source

Medicine To-day [PDF]

BMJ, 1965
openaire   +4 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Society for Veterinary Epidemiology and Preventive Medicine : Proceedings of a meeting held at the University of Bristol on the 24th, 25th and 26th of March 1999

, 1999
Society for Veterinary Epidemiology and Preventive Medicine
core  

Correction: Molecular mechanisms of α-syn abnormal phase separation in cognitive impairment induced by chronic intermittent hypoxia and the neuroprotective effects of Danshensu methyl ester. [PDF]

Mol Med
Li J, Zhang N, Zhang Z, Fu J, Ren W, Sun Y, Song S, Liu X, Liu J, Wang J, Sun Y, Zhang K, Guo R, Lv C, Pan L, Qu G, Han F, Yu Y.   +17 more
europepmc   +1 more source