FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Determinants of organ donation knowledge and attitudes among university students in Oman: a secondary analysis using logistic regression and machine learning. [PDF]
Front Public HealthAltuntas A, Akbulut S, Kucukakcali Z.
europepmc +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Importance of work-related factors for post-retirement labour market participation. [PDF]
PLoS OnePolvinen A, Tenhunen S.
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Impact of community pharmacists on improving polypharmacy in elderly outpatients: a community-based intervention study. [PDF]
J Pharm Health Care SciFuruta T +3 more
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Displacement of synthetic cranioplasty implant due to mechanical failure of titanium fixation plating: illustrative case. [PDF]
J Neurosurg Case LessonsBranscom GA +7 more
europepmc +1 more source
Perceived opportunities and risks of using deepfake technology in grief treatment: a qualitative study among Dutch bereaved people and mental health care workers. [PDF]
Eur J Psychotraumatolvan Oostrum JM, Akalin D, Lenferink L.
europepmc +1 more source