Results 241 to 250 of about 8,801,250 (313)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Barriers and Opportunities to Include Underrepresented Population Groups in Vaccine Trials: Cross-Sectional, Observational, Online Survey Study From the VACCELERATE Research Network.

JMIR Public Health Surveill
Tanriover MD, Poulimeneas D, Tsopela GC, Kopsidas I, Argyropoulos C, Di Marzo R, Valdenmaiier O, Jakobsen SF, Valle Simon P, Carcas-Sansuan AJ, Olesen OF, Cornely OA, Pana ZD, Zaoutis T, Akova M.   +14 more
europepmc   +1 more source

Pediatric dental treatment under general anesthesia: a retrospective analysis of clinical indications and a survey of pediatric dentist referral practices. [PDF]

Front Dent Med
Fux-Noy A, Raz M, Masrawa K, Shmueli A, Halperson E, Moskovitz M.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Sociodemographic Drivers of Delays in Seeking Medical Care in the All of Us Cohort. [PDF]

Nurs Rep
Abegaz TM, Shegena EA, Frietze G, Ahmed M.   +3 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Test-negative Designs with Various Reasons for Testing: Statistical Bias and Solution. [PDF]

Epidemiology
Yu M, Liu TH, Li KQ, Jewell N, Tchetgen Tchetgen E, Small D, Shi X, Wang B.   +7 more
europepmc   +1 more source

Measuring unfinished nursing care in patients with or at risk for delirium: a development and Delphi study. [PDF]

Aging Clin Exp Res
Sist L, Longobucco Y, Messina R, Chiappinotto S, Rucci P, Palese A, UNCSD - Study Group .   +6 more
europepmc   +1 more source

A Retrospective Audit of Healthcare-Associated Infections in Patients Who Are Optimised for Discharge at a Tertiary Medical Centre. [PDF]

Cureus
Barrett C, Shankar Kumar H, Singleton H.
europepmc   +1 more source

Gun ownership for political protection or armed political expression: a nationally representative analysis of differences in 2025 vs. 2023. [PDF]

Inj Epidemiol
Ward JA, Valek RA, Jones VC, Mason L, Crifasi CK.   +4 more
europepmc   +1 more source