Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Assessment of palliative care service utilization and determinant factors among adult cancer patients in Ethiopia: A systematic review and meta-analysis (PRISMA-compliant). [PDF]
Haile GB, Abraha TA.
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Research Utilization: A Cross-Sectional Survey of the Barriers and Facilitators Among Clinical Nurses in Ghana. [PDF]
Surazu B, Sharif AS, Maurice MD.
europepmc +1 more source
Detection of colinear blocks, and synteny and evolutionary analyses based on utilization of MCScanX
Yupeng Wang +5 more
openalex +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Characterizing the Use of Home-Based Behavioral Health Services Among Children in Foster Care. [PDF]
Chorniy A +4 more
europepmc +1 more source
Correction: Surgical Utilization and Outcomes for Patients with Stage IV Melanoma in the Modern Immunotherapy Era [PDF]
Thinzar M. Lwin +4 more
openalex +1 more source
Sporadic utilization of ITN among households with under-five HIV positive children [PDF]
David Ayah Ounah +6 more
openalex +1 more source

