Results 281 to 290 of about 3,961,089 (355)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Developing a Training Program for Healthcare Data Professionals in South Korea: A Needs Analysis. [PDF]

Healthc Inform Res
Kim Y, Moon Y, Jung J, Jeung S, Ji YA, Kim G, Lee Y, Woo H.   +7 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Left ventricular assist device utilization across the different regions of the Netherlands. [PDF]

Neth Heart J
Drost VCE, Wösten M, Otterspoor LC, Damman K, Tops LF, Gianoli M, Kuijpers M, Palmen M, Sjatskig J, Yazdanbakhsh AP, Caliskan K, Van Laake LW.   +11 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Impact of the 2017 ACC/AHA hypertension guidelines on antihypertensive prescribing in the United States: real-world evidence from a nationally representative population. [PDF]

Front Pharmacol
Jafari EA.
europepmc   +1 more source

Association of ZIP code sociodemographic characteristics with radiation oncology services, payments, and technique utilization. [PDF]

Front Oncol
Courtney PT, Sim MS, Eala MA, Liu EY, Shih YT, Steinberg ML, Valle LF, Venkat PS, Xiang MH, Raldow AC.   +9 more
europepmc   +1 more source

Author Correction: Responses in organs, sperm, steroid hormones and CYP450 enzyme in male mice treated by quinestrol only or in conjunction with clarithromycin

Scientific Reports
Yu Ji, Yujie Wang, Yuhang Liu, Yutong Liu, Jiao Qin, Daohuan Yuan, Quansheng Liu   +6 more
doaj   +1 more source

Using DHIS2 routine data for health system preparedness in resource-limited settings: A Bayesian predictive approach in Bangladesh. [PDF]

PLOS Glob Public Health
Shawon TH, Akter E, Ahamed B, Ahmed T, Lubna RA, Biswas A, Ara T, Manna RM, Chandra P, Usmani NG, Hossain MA, Islam MS, Islam SMH, Mahmud S, Siddique AB, Ameen S, Mostari S, Shomik MS, Wilson E, Akseer N, Rahman AE, Arifeen SE, Amouzou A, Hossain AT.   +23 more
europepmc   +1 more source

A Novel Vanadium Redox Flow Battery State of Charge Estimation Method Utilizing Convolutional Neural Network and Gated Recurrent Unit for Different Operating Conditions

Runtian Li, Yue Wang, Tianyi Zhang
openalex   +1 more source