Results 191 to 200 of about 120,368 (234)

Design, Optimization and Mechanistic Insights Into Terpenoid‐Derived Inhibitors of Protein Kinase C Iota

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
In this study, we identified a synthetic naphthoquinone merosesquiterpene as a potent PKCι inhibitor, emerging as the most strongly inhibited kinase within a panel of 410 human kinases. Structure–activity relationship (SAR) studies using a focused library of terpenoid analogues highlighted the critical role of the naphthoquinone core and the aromatic ...
Rachid Chahboun, Fernando Rodríguez‐Serrano, Ángel Bueno, Nuria Mut‐Salud, Ramón Alvarez‐Manzaneda, Enrique Alvarez‐Manzaneda, Antonio Fernández   +6 more
wiley   +1 more source

RBM10 modulation of circRNA biogenesis contributes to its tumor suppressor role in lung adenocarcinoma. [PDF]

Biomark Res
Utrilla-Maestre A, Matia-González AM, Peinado P, Becerra-Rodriguez MA, Benitez-Cantos MS, Cuadros M, Medina PP.   +6 more
europepmc   +1 more source

Multiple global‐change drivers and cascading effects in Mediterranean ecosystems: Lessons from an iconic national park

Conservation Science and Practice, Volume 8, Issue 6, June 2026.
Mediterranean ecosystems face complex, multi‐trophic impacts from global‐change drivers, yet responses are often studied in isolation. Using the Doñana Protected Area as a case study, we illustrate how anthropogenic pressures on key species like cork oaks and rabbits, as well as increases in species like wild boar and invasive crayfish, lead to ...
Maria Paniw, Duarte S. Viana, Cristina Coccia, Virginia Domínguez‐García, Iñigo Donázar‐Aramendía, Sebastiano de Franciscis, Alberto García‐Rodríguez, Simone Guareschi, Pablo Homet, Jose B. Lanuza, Cosme López‐Calderón, Irene Mendoza, Eva Moracho, Laetitia M. Navarro, Javier Puy, José M. Reyes‐González, María José Ruiz‐López, Zulima Tablado, Elena Tena, Estefanía Tobajas, Elena Velado‐Alonso, Pablo Villalva, Nacho Villar, Marcello D'Amico   +23 more
wiley   +1 more source

Differences in Game Meat Consumer Behaviour in a Game Meat-Producing Region: The Case of Andalusia. [PDF]

Foods
Pérez Hernández PP, Martín Lozano JM, Velasco MR, Cenizo PA.   +3 more
europepmc   +1 more source

Validation of masturbation parameters: A laboratory study measuring psychophysiological and subjective sexual arousal. [PDF]

Int J Clin Health Psychol
Sánchez-Pérez GM, Granados R, Mangas P, Cervilla O, Sierra JC.   +4 more
europepmc   +1 more source

[Impact of the Healthcare Triad Model on Primary Care accessibility: a quasi-experimental before-and-after study]. [PDF]

Aten Primaria
Cañas Tornero F, Monge García MI, González Soria L, Rabadán Asencio A.   +3 more
europepmc   +1 more source

Regeneration of an Extracellular Matrix Ecosystem Following Subcutaneous Injection With Different Radiesse Dilutions: A Histologic and Ultrasound Study

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Calcium hydroxylapatite‐carboxymethylcellulose (CaHA‐CMC) stimulates neocollagenesis across a range of dilutions; however, the magnitude and temporal profile of this bioregenerative response have not yet been comprehensively examined.
Kate Goldie, Gabriela Casabona, Niamh Corduff, Alec D. McCarthy, Kristina Riegel   +4 more
wiley   +1 more source

Masters and Slaves in Empty Spain: A Philosophical–Political Reading of Rural Depopulation

Sociology Lens, Volume 39, Issue 2, Page 263-276, June 2026.
ABSTRACT Rural depopulation in Spain reveals not only demographic decline but also the persistence of unequal power structures. Drawing on the classical elite theories of Pareto, Mosca, and Michels, alongside Hegel's master–slave dialectic, this article offers a socio‐philosophical and political interpretation of the phenomenon.
Leandro Sebastián Fervier, Victoria Sanagustín‐Fons   +1 more
wiley   +1 more source

Trajectory of genome editing technology. [PDF]

BMC Biol
Luo Y, Ceasar SA, Benabdellah K.
europepmc   +1 more source

Assessing Patient Safety Culture in Hospital at Home Services Across Spain Through a National Survey

Nursing &Health Sciences, Volume 28, Issue 2, June 2026.
ABSTRACT Patient Safety Culture (PSC) is key to healthcare quality. While widely studied in hospitals, evidence on PSC in Hospital at Home (HaH)—a growing model delivering hospital‐level care at home—remains scarce. This study evaluated PSC among professionals in Spanish public HaH units.
Nina Granel, Eva Angels Sanchez Martos, Mireia Subirana‐Casacuberta, Carolina E. Watson, Rebeca Gomez‐Ibáñez, Ester Risco   +5 more
wiley   +1 more source