Results 61 to 70 of about 2,246,673 (121)

Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1

Frontiers in Physiology, 2015
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are widely used in studying basic mechanisms of cardiac arrhythmias that are caused by ion channelopathies.
Rosalie M.E. Meijer van Putten, Isabella eMengarelli, Kaomei eGuan, Jan G. Zegers, Antoni CG van Ginneken, Arie O Verkerk, Ronald eWilders   +6 more
doaj   +1 more source

Identification of a PEST Sequence in Vertebrate KIR2.1 That Modifies Rectification

Frontiers in Physiology, 2019
KIR2.1 potassium channels, producing inward rectifier potassium current (IK1), are important for final action potential repolarization and a stable resting membrane potential in excitable cells like cardiomyocytes.
Muge Qile, Yuan Ji, Marien J. C. Houtman, Marlieke Veldhuis, Fee Romunde, Bart Kok, Marcel A. G. van der Heyden   +6 more
doaj   +1 more source

Kir2.1 mutations differentially increase the risk of flecainide proarrhythmia in Andersen Tawil Syndrome

medRxiv
Background: Flecainide and other class-Ic antiarrhythmic drugs (AADs) are widely used in Andersen-Tawil syndrome type 1 (ATS1) patients. However, class-Ic drugs might be proarrhythmic in some cases.
F. M. Cruz, A. Moreno-Manuel, Sánchez Pérez Patricia, Juan Manuel Ruiz-Robles, P. G. Socuéllamos, L. Gutierrez, M. L. Vera-Pedrosa, Amaia Talavera Gutierrez, Gema Mondéjar Parreño, Á. Macías, I. Martínez-Carrascoso, F. Bermúdez-Jiménez, Salvador Arias Santiago, Fernando Martínez de Benito, Aitana Braza-Boils, Carmen Valenzuela, Carlos A. Morillo, Esther Zorio, J. Jiménez-Jáimez, José Jalife   +19 more
semanticscholar   +1 more source

Standard Poster Abstracts for the 17th Asia Pacific Heart Rhythm Society (APHRS) Scientific Sessions

Journal of Arrhythmia, Volume 41, Issue 2, April 2025.
wiley   +1 more source

Broad Electrocardiogram Syndromes Spectrum: From Common Emergencies to Particular Electrical Heart Disorders—Part II

Diagnostics
The electrocardiogram (ECG) remains a cornerstone of modern cardiology, providing rapid, non-invasive, and widely accessible diagnostic insights. While ECG interpretation is an essential skill for clinicians, certain patterns can be subtle or atypical ...
Alexandr Ceasovschih, Anastasia Balta, Victorița Șorodoc, Krishnaraj Rathod, Ahmed El Gohary, Serghei Covantsev, Richárd Masszi, Yusuf Ziya Şener, Alexandru Corlăteanu, Syed Haseeb Raza Naqvi, Alexandra Grejdieru, Nicholas G. Kounis, Laurențiu Șorodoc   +12 more
doaj   +1 more source

Paroxysmal limb weakness for ten years

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
DOI: 10.3969/j.issn.1672-6731.2017.07 ...
Meng-yu ZHANG, Yan XU, Jian-zhong SHEN, Yin-chang YANG, Bin PENG, Li-ying CUI   +5 more
doaj  

Atomic-level investigation of KCNJ2 mutations associated with ventricular arrhythmic syndrome phenotypes

Scientific Reports
KCNJ2 encodes the inward rectifying potassium channel (Kir2.1) that underlies I K1 which maintains the cardiac resting membrane potential and regulates excitability.
Saba Munawar, Corey L. Anderson, Louise Reilly, Ryan Woltz, Yusra Sajid Kiani, Nipavan Chiamvimonvat, Lee L. Eckhardt   +6 more
doaj   +1 more source

Rare electrocardiographic findings in a young woman with acute barium poisoning: A case report

Heliyon
Background: Barium, as a heavy divalent alkaline earth metal, can be found in various products such as rodenticides, insecticides, depilatories, and fireworks. Barium can be highly toxic upon both acute and chronic exposure.
Yubin Zhang, Xi Huang, Yiru Han, Ren Yan
doaj   +1 more source

Transcriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome type 7

Journal of Translational Medicine
Objective Long QT syndrome type 7 (Andersen–Tawil syndrome, ATS), which is caused by KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal malformations.
Peipei Chen, Junyu Long, Tianrui Hua, Zhifa Zheng, Ying Xiao, Lianfeng Chen, Kang Yu, Wei Wu, Shuyang Zhang   +8 more
doaj   +1 more source

Clinodactyly and syndactyly – diagnostic clues for Andersen-Tawil syndrome

Arquivos de Neuro-Psiquiatria, 2014
Carlos Andrade, Joana Meireles, Miguel Leão, Fernando Silveira   +3 more
doaj   +1 more source