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Turkish Journal of Hematology, 2012 Although corticosteroids are the main drugs for the treatment of AIHA, it should not be used in divided doses as subtitution treatment as of surrenal insufficiency; which has been applied previously; Rather it should be given at once around 6 a.m preferentially as Megadose methylprednisolone (MDMP) [4] intravenously or orally as desribed by us which ...
Şinasi Özsoylu
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Complement in hemolytic anemia [PDF]
Hematology, 2015 Complement is increasingly being recognized as an important driver of human disease, including many hemolytic anemias. Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55.
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Autoimmune hemolytic anemia [PDF]
Hematology, 2018 AbstractThe diagnosis of autoimmune hemolytic anemia (AIHA) can be made with a stepwise approach that aims to identify laboratory and clinical evidence of hemolysis and then determine the immune nature of hemolysis with the direct anti-globulin test. Once alternative causes for these findings have been excluded, AIHA is established, and the clinician ...
Quentin A. Hill, Anita J. Hill
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Current Opinion in Immunology, 1994 Autoimmune hemolytic anemia (AHA) is characterized by the production of Coombs' antibodies, which are responsible for the destruction of red blood cells (RBCs). Analysis of both monoclonal anti-RBC autoantibodies derived from autoimmune New Zealand black mice and transgenic mice expressing a pathogenic IgM anti-RBC autoantibody has considerably ...
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Metformin-Induced Hemolytic Anemia [PDF]
Medical Principles and Practice, 2013 <b><i>Objective:</i></b> To report a rare side effect of metformin, an oral antidiabetic drug that is used for the treatment of type 2 diabetes mellitus. <b><i>Clinical Presentation and Intervention:</i></b> A 17-year-old boy was hospitalized for receiving acute lymphoblastic leukemia treatment that was ...
Kirkiz, Serap +3 more
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Clinics in Laboratory Medicine, 1999 This article provides an overview of hemolytic anemia in children. Main focus areas include acquired immune-mediated hemolysis, hemolytic anemia due to hereditary RBC disorders, hereditary hemolytic disorders caused by enzyme abnormalities, and hereditary hemolytic anemia due to hemoglobin abnormalities.
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Annals of Pathology and Laboratory Medicine, 2018 A 5 days old male neonate was brought with icterus till forearms and legs with no other associated symptoms. He was born to a 30 year old second gravida lady with mother’s blood group being B positive and perinatal transition being uneventful. Investigations revealed unconjugated hyperbilirubinemia nearing exchange transfusion range with severe ...
Divya Gupta, Parminder Singh
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, 2014 Autoimmune hemolytic anemia (AIHA) is a classic example of type II hypersensitivity, caused by autoantibodies that bind red blood cells (RBC). The autoantibodies can be divided into cold or warm types, depending on the optimum temperature at which they bind, and AIHA can also be classified as either primary or secondary if there is an underlying ...
Robert N. Barker, Mark A. Vickers
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Coagulation in the Pathophysiology of Hemolytic Anemias
Hematology, 2007 AbstractCoagulation abnormalities are frequently reported in hemolytic anemias (HA). Several pathophysiologic mechanisms are common to different HA. In this review three different hemolytic disorders will be discussed.In sickle cell disease and in β-thalassemia, a thrombophilic status has been well documented as multifactorial involving hemostatic ...
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