Results 71 to 80 of about 85,301 (285)

Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes. [PDF]

, 2009
BackgroundA growing number of realistic in silico models of metabolic functions are being formulated and can serve as 'dry lab' platforms to prototype and simulate experiments before they are performed.
Jamshidi, Neema, Palsson, Bernhard O
core   +3 more sources

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

ChemMedChem, EarlyView.
This study reports novel 5‐HMF analogs with potent antisickling activities. Lead compound MMA509 enhances hemoglobin oxygen affinity and prevents erythrocyte sickling. Crystal structure of hemoglobin‐MMA509 complex explains MMA509 mechanism of action. An IV formulation is successfully developed, positioning MMA509 as a promising fast‐acting treatment ...
Abdelsattar M. Omar, Moustafa E. El‐Araby, Tarek A. Ahmed, Akua K. Donkor, Albert Opare, Mohini S. Ghatge, Anfal S. Aljahdali, Rana T. Alhashimi, Trevohn N. Robinson, Benita Balogun, Mariana Macias, Salma Roland, Yan Zhang, Faik N. Musayev, Osheiza Abdulmalik, Martin K. Safo   +15 more
wiley   +1 more source

Characterisation of the Immunophenotype of Dogs with Primary Immune-Mediated Haemolytic Anaemia [PDF]

, 2016
Immune-mediated haemolytic anaemia (IMHA) is reported to be the most common autoimmune disease of dogs, resulting in significant morbidity and mortality in affected animals.
A Corato, A Doganci, A Knueppel, A Kojima, A Mqadmi, A Saxena, A Zanella, AL Rivas, AM Hall, AM Hall, B Sadlack, Barbara Glanemann, CA Lawson, CJ Elson, CJ Piek, CL Bennett, D Cao, D Pinheiro, DM Willerford, Douglas Thamm, E Ahmad, E Fagiolo, E Fagiolo, E Fagiolo, E Fagiolo, E von Elm, FJ Ward, G Kleiner, HF Titmarsh, James W. Swann, JH Buckner, JM Kim, JS Ellis, JW Swann, K Wing, KD Mitchell, Kelly Woods, KY King, L Han, L Llorente, L Llorente, L Xu, M Kjelgaard-Hansen, M Miyara, M Murai, MA Miller, ME Brunkow, NJ Davidson, NV Giltiay, OA Garden, Oliver A. Garden, P Pietschmann, PM McManus, RN Barker, RS Wildin, S Aggarwal, S Berentsen, S Lindley, S McCullough, S Sakaguchi, SA Bustin, SJ Ireland, V Viglietta, X Valencia, Ying Wu, Z Jiao   +65 more
core   +11 more sources

Infantile Cytomegalovirus-Associated Severe Warm Autoimmune Hemolytic Anemia: A Case Report

Children, 2017
Autoimmune hemolytic anemia is a rare hematologic entity in children. Etiologies are mainly viruses or bacteria. We describe here a case of severe warm autoimmune hemolytic anemia (IgG- and C3d-positive direct antiglobulin test) in an immunocompetent 6 ...
Hassan K. Khalifeh, Youmna M. Mourad, Cynthia T. Chamoun   +2 more
doaj   +1 more source

Mycoplasma suis infection in suckling pigs on a Belgian farm [PDF]

, 2008
Mycoplasma suis (formerly known as Eperythrozoon suis) is an epicellular bacterium that affects porcine red blood cells. M. suis infections occur worldwide and are associated with weakness and anemia in suckling and weaned pigs, and reproductive ...
De Busser, Emily Valerie, Haesebrouck, Freddy, Hoelzle, LE, Maes, Dominiek, Mateusen, Bart, Vicca, Jo   +5 more
core   +1 more source

Can we continue research in splenectomized dogs? Mycoplasma haemocanis: Old problem - New insight [PDF]

, 2004
We report the appearance of a Mycoplasma haemocanis infection in laboratory dogs, which has been reported previously, yet, never before in Europe. Outbreak of the disease was triggered by a splenectomy intended to prepare the dogs for a hemorrhagic shock
A. Schropp, Benjamin MM, Berent LM, Birkenheuer A, Brinson J, Brodey RS, C. Wojtczyk, Crowell JW, Davies BN, Donovan EF, Dunham CM, E. Thein, F. Meisner, G. Enders, G. Kemming, Gretillat S, H. Kisch-Wedel, Hartwig G, Hoskins JD, J.B. Messick, K. Messmer, K. Packert, Krakowka S, Lester SL, Messick JB, Pryor, S. Muenzing, Seneviratna P, Venable JH, W. Mueller, Walcott WW, West HJ, Wiggers CJ, Withrington PG, Wright IG, Zweifach BW   +35 more
core   +1 more source

Safety, Pharmacokinetics, and Pharmacodynamics of Osivelotor for Sickle Cell Disease: First‐in‐Human Studies in Healthy Participants and Patients

Clinical Pharmacology &Therapeutics, EarlyView.
The investigational agent osivelotor, a small molecule hemoglobin (Hb) modifier in development for the treatment of sickle cell disease (SCD), acts by increasing Hb‐oxygen affinity and inhibiting the polymerization of sickle Hb. We report safety, pharmacokinetic (PK), and pharmacodynamic (PD) data from the first two phase 1 clinical trials of ...
Eleanor A. Lisbon, R. Clark Brown, Andrew Redfern, Ken Duchin, Aline Barth, Erika S. Roberts, Polo Gaputan, Kobina Dufu, Arthur Lo, Mira Patel Pochron, David R. Archer, Wai Chin, Karena Kong, Carla B. Washington, Adeyemi Adenola, Eric I. Zimmerman   +15 more
wiley   +1 more source

Sublytic Terminal Complement Components Induce Eryptosis in Autoimmune Haemolytic Anaemia Related to IgM Autoantibodies [PDF]

, 2019
BACKGROUND/AIMS: Eryptosis, the suicidal death of red blood cells (RBCs), is characterized by phosphatidylserine (PS) exposure at the cell surface. It can be catalysed by a variety of abnormal conditions and diseases.
Balola, Abdelwahab Hassan Ahmed, Bartolmäs, Thilo, Mayer, Beate, Salama, Abdulgabar   +3 more
core   +1 more source

Hereditary Spherocytosis due to an SPTA1 Nonsense Mutation Coinherited With α spectrinLELY in Trans

American Journal of Hematology, EarlyView.
María‐Angustias Molina‐Arrebola, Barbara J. Bain   +1 more
wiley   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source