Results 131 to 140 of about 63,448 (245)

Talazoparib Formulation Bridging in Cancer Patients—Challenges and the Critical Role of Model‐Informed Drug Development in Approval Despite Failed Bioequivalence

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Talazoparib is a poly(ADP‐ribose) polymerase inhibitor approved for the treatment of breast and prostate cancer. Commercialization of a soft gelatin capsule (SGC) formulation developed post‐approval required a bioequivalence (BE) and food effect (FE) study to bridge SGC with the initial commercial hard capsule (HC) formulation. Study execution
Diane Wang   +10 more
wiley   +1 more source

Molecularly Engineered Fluorescent Magnetic Microrobots for Sensing High‐Energy Nitroaromatic Explosives in Highly Acidic Aqueous Environments

open access: yesSmall, EarlyView.
Magnetically powered fluorescent microrobots embedded with ketenimine‐based probes enable remote sensing of high‐energy explosive compounds in harsh acidic environments. Upon interaction with picric acid, the fluorescence of the microrobots is quenched, providing a precise “on–off” detection mechanism for selective monitoring in confined and hazardous ...
Nikhil Thekkedath Madhu   +2 more
wiley   +1 more source

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

open access: yesSmart Molecules, EarlyView.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan   +4 more
wiley   +1 more source

International Practice Variation in Post‐Tonsillectomy Hemorrhage: A Survey Study of Pediatric Otolaryngologists

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background A significant complication of pediatric tonsillectomy is post‐tonsillectomy bleeding (PTB). Management within and outside of the operating room (OR) is not standardized. We consolidated international similarities and differences in PTB management.
Gina M. Spencer   +8 more
wiley   +1 more source

Dysphagia in Children With Autism Spectrum Disorder: A Scoping Review

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective There are four phases of swallowing: oral preparatory, oral transit, oropharyngeal, and esophageal. Disruption of any phase(s) can lead to dysphagia. Autism spectrum disorder (ASD) children have a high rate of dysphagia compared with neurotypical peers.
Chase Hintelmann   +3 more
wiley   +1 more source

Where's the beef? The feminisation of weight‐loss dieting in Britain and Scandinavia c.1890–1925

open access: yesGender &History, EarlyView.
Abstract Representations of the slim body have traditionally been at the centre of scholarly interest in dieting culture, whereas food often remains a shadowy presence compared with more persistent themes of body discipline, slenderness and anti‐fat messages.
Emma Hilborn
wiley   +1 more source

Celiac disease and iron deficiency. [PDF]

open access: yesCMAJ
Farid M   +4 more
europepmc   +1 more source

Exploring factors influencing complementary feeding practices in Asia from parents' and caregivers' perspectives: A qualitative systematic review

open access: yesNutrition &Dietetics, EarlyView.
Abstract Aims Child malnutrition remains a significant issue worldwide, particularly in developing regions like Asia. Age 6–23 months is critical for preventing malnutrition, yet numerous children within this range do not receive nutritionally sufficient complementary foods.
Intan Noor Hanifa   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy